rs1426371

This is a regulatory region variant variant in the WSCD2 gene.

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GWAS Catalog Trait Associations (16)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

type 2 diabetes mellitus

Suzuki K et al. “Genetic drivers of heterogeneity in type 2 diabetes pathophysiology.” Nature 627(8003):347-357 (2024)

Allele G

OR —

p 2.0e-34

N 2,535,601

Large GWAS

multi-ancestry

Elashi AA et al. “Genome-wide association study and trans-ethnic meta-analysis identify novel susceptibility loci for type 2 diabetes mellitus.” Bmc Medical Genomics 17(1):115 (2024)

Allele G

OR 0.05

p 2.0e-18

N 6,710,881

Meta-analysisLarge GWAS

multi-ancestry

Vujkovic M et al. “Discovery of 318 new risk loci for type 2 diabetes and related vascular outcomes among 1.4 million participants in a multi-ancestry meta-analysis.” Nature Genetics 52(7):680-691 (2020)

Allele G

OR 0.04

p 1.0e-21

N 1,407,282

Meta-analysisLarge GWAS

multi-ancestry

Mahajan A et al. “Fine-mapping type 2 diabetes loci to single-variant resolution using high-density imputation and islet-specific epigenome maps.” Nature Genetics 50(11):1505-1513 (2018)

Allele G

OR 1.05

p 8.0e-12

N 898,130

Large GWAS

European

Sakaue S et al. “A cross-population atlas of genetic associations for 220 human phenotypes.” Nature Genetics 53(10):1415-1424 (2021)

Allele G

OR 0.05

p 2.0e-13

N 667,504

Large GWAS

multi-ancestry

Mahajan A et al. “Multi-ancestry genetic study of type 2 diabetes highlights the power of diverse populations for discovery and translation.” Nature Genetics 54(5):560-572 (2022)

Allele G

OR 1.05

p 3.0e-18

N 492,192

Large GWAS

multi-ancestry

Spracklen CN et al. “Identification of type 2 diabetes loci in 433,540 East Asian individuals.” Nature 582(7811):240-245 (2020)

Allele G

OR 1.05

p 8.0e-12

N 433,540

Large GWAS

East Asian

extraversion

Lo MT et al. “Genome-wide analyses for personality traits identify six genomic loci and show correlations with psychiatric disorders.” Nature Genetics 49(1):152-156 (2017)

Allele A

OR 0.02

p 1.0e-14

N 122,886

Large GWAS

European

osteoarthritis, knee, body mass index

Zhang L et al. “A sex- and site-specific relationship between body mass index and osteoarthritis: evidence from observational and genetic analyses.” Osteoarthritis and Cartilage 31(6):819-828 (2023)

Allele A

OR —

p 2.0e-14

N 1,202,888

Large GWAS

European

fat pad mass

Loya H et al. “A scalable variational inference approach for increased mixed-model association power.” Nature Genetics 57(2):461-468 (2025)

Allele A

OR 0.02

p 6.0e-13

N 394,642

Large GWAS

European

Harris BHL et al. “New role of fat-free mass in cancer risk linked with genetic predisposition.” Scientific Reports 14(1):7270 (2024)

Allele A

OR 0.01

p 3.0e-8

N 337,196

Large GWAS

European

osteoarthritis, knee

Hatzikotoulas K et al. “Translational genomics of osteoarthritis in 1,962,069 individuals.” Nature 641(8065):1217-1224 (2025)

Allele A

OR 0.97

p 1.0e-12

N 1,316,500

Large GWAS

multi-ancestry

Boer CG et al. “Deciphering osteoarthritis genetics across 826,690 individuals from 9 populations.” Cell 184(18):4784-4818.e17 (2021)

Allele A

OR 0.95

p 9.0e-10

N 396,044

Large GWAS

multi-ancestry

osteoarthritis, hip, osteoarthritis, knee, total joint arthroplasty

Hatzikotoulas K et al. “Translational genomics of osteoarthritis in 1,962,069 individuals.” Nature 641(8065):1217-1224 (2025)

Allele A

OR 0.95

p 3.0e-12

N 866,417

Large GWAS

multi-ancestry

alcohol consumption quality

Saunders GRB et al. “Genetic diversity fuels gene discovery for tobacco and alcohol use.” Nature 612(7941):720-724 (2022)

Allele A

OR 0.01

p 4.0e-12

N 2,428,851

Large GWAS

European

Liu M et al. “Association studies of up to 1.2 million individuals yield new insights into the genetic etiology of tobacco and alcohol use.” Nature Genetics 51(2):237-244 (2019)

Allele A

OR 0.01

p 6.0e-9

N 1,039,210

Large GWAS

European

phospholipids in small HDL measurement

Zoodsma M et al. “A genetic map of human metabolism across the allele frequency spectrum.” Nature Genetics 57(10):2445-2455 (2025)

Allele A

OR 0.02

p 3.0e-11

N 450,015

Large GWAS

multi-ancestry

total lipids in small HDL measurement

Zoodsma M et al. “A genetic map of human metabolism across the allele frequency spectrum.” Nature Genetics 57(10):2445-2455 (2025)

Allele A

OR 0.02

p 3.0e-11

N 450,015

Large GWAS

multi-ancestry

appendicular lean mass

Hernandez Cordero AI et al. “Genome-wide Associations Reveal Human-Mouse Genetic Convergence and Modifiers of Myogenesis, CPNE1 and STC2.” American Journal of Human Genetics 105(6):1222-1236 (2019)

Allele A

OR 0.08

p 4.0e-11

N 85,750

Large GWAS

European

About WSCD2

Predicted to enable sulfotransferase activity. Predicted to be located in Golgi membrane. [provided by Alliance of Genome Resources, Jul 2025]

rs1426371

GWAS Catalog Trait Associations (16)

type 2 diabetes mellitus

extraversion

osteoarthritis, knee, body mass index

fat pad mass

osteoarthritis, knee

osteoarthritis, hip, osteoarthritis, knee, total joint arthroplasty

alcohol consumption quality

phospholipids in small HDL measurement

total lipids in small HDL measurement

appendicular lean mass

About WSCD2

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