Trait
SNPs associated with Osteoarthritis, Knee
222 genetic variants across 67 genes have been associated with Osteoarthritis, Knee in published research. Key genes include AP3B1, APOE, ARNTL.
Associated variants222 total
| rsid | Gene | Effect | Evidence |
|---|---|---|---|
| rs12310519 | — | GWAS association (p=1.0e-25) | Meta-analysis |
| rs143384 | GDF5 | GWAS association (p=1.0e-23) | Meta-analysis |
| rs1078301 | LOC105376225 | GWAS association (p=7.0e-18) | Meta-analysis |
| rs143383 | GDF5 | GWAS association (p=8.0e-18) | Meta-analysis |
| rs7225843 | — | GWAS association (p=4.0e-16) | Meta-analysis |
| rs111837947 | — | GWAS association (p=1.0e-15) | Meta-analysis |
| rs72760655 | — | GWAS association (p=1.0e-14) | Meta-analysis |
| rs117018441 | EP300 | GWAS association (p=2.0e-13) | Meta-analysis |
| rs34195470 | — | GWAS association (p=3.0e-13) | Meta-analysis |
| rs2061026 | — | GWAS association (p=1.0e-11) | Meta-analysis |
| rs11383210 | — | GWAS association (p=2.0e-11) | Meta-analysis |
| rs4865462 | — | GWAS association (p=5.0e-11) | Meta-analysis |
| rs2605091 | LYPLAL1-AS1 | GWAS association (p=5.0e-11) | Meta-analysis |
| rs4775006 | — | GWAS association (p=1.0e-10) | Meta-analysis |
| rs6966540 | — | GWAS association (p=2.0e-10) | Meta-analysis |
| rs72979233 | — | GWAS association (p=5.0e-10) | Meta-analysis |
| rs2447606 | ATG7 | GWAS association (p=9.0e-10) | Meta-analysis |
| rs6707054 | BABAM2 | GWAS association (p=2.0e-09) | Meta-analysis |
| rs74860745 | — | GWAS association (p=3.0e-09) | Meta-analysis |
| rs1790132 | MPHOSPH9 | GWAS association (p=3.0e-09) | Meta-analysis |
| rs28929474 | SERPINA1 | GWAS association (p=1.0e-08) | Meta-analysis |
| rs1060105 | — | GWAS association (p=2.0e-08) | Meta-analysis |
| rs11731421 | — | GWAS association (p=2.0e-32) | Major Consortium Study |
| rs3755381 | TGFA | GWAS association (p=7.0e-20) | Major Consortium Study |
| rs35697691 | — | GWAS association (p=3.0e-18) | Major Consortium Study |
| rs13107325 | SLC39A8 | GWAS association (p=3.0e-18) | Major Consortium Study |
| rs11638576 | — | GWAS association (p=1.0e-12) | Major Consortium Study |
| rs17567417 | — | GWAS association (p=2.0e-12) | Major Consortium Study |
| rs113179593 | LOC102724542 | GWAS association (p=2.0e-12) | Major Consortium Study |
| rs75621460 | — | GWAS association (p=6.0e-12) | Major Consortium Study |
| rs59323233 | — | GWAS association (p=6.0e-12) | Major Consortium Study |
| rs34592089 | — | GWAS association (p=7.0e-12) | Major Consortium Study |
| rs7396943 | ARNTL | GWAS association (p=8.0e-12) | Major Consortium Study |
| rs12978481 | C19orf38 | GWAS association (p=2.0e-11) | Major Consortium Study |
| rs9277511 | HLA-DPB1 | GWAS association (p=3.0e-11) | Major Consortium Study |
| rs6499244 | — | GWAS association (p=4.0e-11) | Major Consortium Study |
| rs8067763 | — | GWAS association (p=1.0e-10) | Major Consortium Study |
| rs4985464 | CLEC18A | GWAS association (p=1.0e-10) | Major Consortium Study |
| rs56116847 | — | GWAS association (p=3.0e-10) | Major Consortium Study |
| rs4978572 | — | GWAS association (p=4.0e-10) | Major Consortium Study |
| rs56305262 | — | GWAS association (p=5.0e-10) | Major Consortium Study |
| rs10947428 | — | GWAS association (p=5.0e-10) | Major Consortium Study |
| rs7581258 | LTBP1 | GWAS association (p=7.0e-10) | Major Consortium Study |
| rs6986032 | — | GWAS association (p=8.0e-10) | Major Consortium Study |
| rs35087650 | — | GWAS association (p=1.0e-09) | Major Consortium Study |
| rs7819602 | — | GWAS association (p=1.0e-09) | Major Consortium Study |
| rs216195 | — | GWAS association (p=2.0e-09) | Major Consortium Study |
| rs557675 | — | GWAS association (p=6.0e-09) | Major Consortium Study |
| rs11634109 | — | GWAS association (p=6.0e-09) | Major Consortium Study |
| rs11690912 | — | GWAS association (p=7.0e-09) | Major Consortium Study |
| rs35611929 | AP3B1 | GWAS association (p=1.0e-08) | Major Consortium Study |
| rs2732441 | H1-7 | GWAS association (p=1.0e-08) | Major Consortium Study |
| rs11030104 | BDNF | GWAS association (p=1.0e-08) | Major Consortium Study |
| rs11168366 | LOC105369750 | GWAS association (p=1.0e-08) | Major Consortium Study |
| rs4543129 | — | GWAS association (p=1.0e-08) | Major Consortium Study |
| rs6903171 | — | GWAS association (p=1.0e-08) | Major Consortium Study |
| rs9277861 | LOC105375021 | GWAS association (p=1.0e-08) | Major Consortium Study |
| rs35912128 | — | GWAS association (p=2.0e-08) | Major Consortium Study |
| rs12470967 | LOC729254 | GWAS association (p=2.0e-08) | Major Consortium Study |
| rs9277552 | HLA-DPB1 | GWAS association (p=2.0e-08) | Major Consortium Study |
| rs61953491 | — | GWAS association (p=2.0e-08) | Major Consortium Study |
| rs111591982 | — | GWAS association (p=2.0e-08) | Major Consortium Study |
| rs6928965 | — | GWAS association (p=2.0e-08) | Major Consortium Study |
| rs144056477 | — | GWAS association (p=3.0e-08) | Major Consortium Study |
| rs382603 | LOC107984419 | GWAS association (p=3.0e-08) | Major Consortium Study |
| rs10875467 | — | GWAS association (p=3.0e-08) | Major Consortium Study |
| rs1079359 | — | GWAS association (p=3.0e-08) | Major Consortium Study |
| rs28405622 | — | GWAS association (p=3.0e-08) | Major Consortium Study |
| rs71659381 | — | GWAS association (p=4.0e-08) | Major Consortium Study |
| rs62194158 | ICA1L | GWAS association (p=4.0e-08) | Major Consortium Study |
| rs4818310 | — | GWAS association (p=4.0e-08) | Major Consortium Study |
| rs150116001 | PHF20 | GWAS association (p=4.0e-08) | Major Consortium Study |
| rs2137058 | — | GWAS association (p=5.0e-08) | Major Consortium Study |
| rs2176630 | — | GWAS association (p=5.0e-08) | Major Consortium Study |
| rs158146 | DCDC1 | GWAS association (p=5.0e-08) | Major Consortium Study |
| rs224333 | GDF5 | GWAS association (p=6.0e-42) | Large GWAS |
| rs9930333 | FTO | GWAS association (p=8.0e-38) | Large GWAS |
| rs4606747 | — | GWAS association (p=3.0e-30) | Large GWAS |
| rs12509303 | — | GWAS association (p=9.0e-25) | Large GWAS |
| rs10131337 | — | GWAS association (p=9.0e-23) | Large GWAS |
| rs3755380 | TGFA | GWAS association (p=3.0e-22) | Large GWAS |
| rs429358 | APOE | GWAS association (p=8.0e-22) | Large GWAS |
| rs3843750 | SLC44A2 | GWAS association (p=2.0e-20) | Large GWAS |
| rs10048129 | WWP2 | GWAS association (p=1.0e-19) | Large GWAS |
| rs12978179 | DOT1L | GWAS association (p=2.0e-19) | Large GWAS |
| rs876122 | — | GWAS association (p=8.0e-19) | Large GWAS |
| rs148024643 | SNRPC | GWAS association (p=2.0e-18) | Large GWAS |
| rs2605111 | — | GWAS association (p=5.0e-18) | Large GWAS |
| rs62070652 | — | GWAS association (p=7.0e-18) | Large GWAS |
| rs12911554 | — | GWAS association (p=2.0e-16) | Large GWAS |
| rs2867109 | — | GWAS association (p=3.0e-16) | Large GWAS |
| rs9533090 | — | GWAS association (p=4.0e-16) | Large GWAS |
| rs4425336 | FAM13A | GWAS association (p=4.0e-15) | Large GWAS |
| rs10878346 | — | GWAS association (p=1.0e-14) | Large GWAS |
| rs12214906 | — | GWAS association (p=1.0e-14) | Large GWAS |
| rs60558455 | — | GWAS association (p=3.0e-14) | Large GWAS |
| rs11749736 | SPRY4-AS1 | GWAS association (p=9.0e-14) | Large GWAS |
| rs3774364 | ITIH4 | GWAS association (p=1.0e-13) | Large GWAS |
| rs1059698 | — | GWAS association (p=1.0e-13) | Large GWAS |
| rs10974438 | — | GWAS association (p=3.0e-13) | Large GWAS |
Showing the top 100 of 222 variants by evidence strength.
Associations aggregated from the GWAS Catalog and curated literature. Informational only — not medical advice.