rs3755381

This variant is located in the TGFA gene.

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GWAS Catalog Trait Associations (2)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

osteoarthritis, knee

Hollis B et al. “Lifetime risk and genetic predisposition to post-traumatic OA of the knee in the UK Biobank.” Osteoarthritis and Cartilage 31(10):1377-1387 (2023)
Allele C
OR 1.05
p 7.0e-20
N 354,561
Major Consortium StudyLarge GWAS
European

osteoarthritis, knee, total knee arthroplasty

Hatzikotoulas K et al. “Translational genomics of osteoarthritis in 1,962,069 individuals.” Nature 641(8065):1217-1224 (2025)
Allele T
OR 1.05
p 1.0e-12
N 1,006,624
Large GWAS
multi-ancestry

About TGFA

This gene encodes a growth factor that is a ligand for the epidermal growth factor receptor, which activates a signaling pathway for cell proliferation, differentiation and development. This protein may act as either a transmembrane-bound ligand or a soluble ligand. This gene has been associated with many types of cancers, and it may also be involved in some cases of cleft lip/palate. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]

View all TGFA variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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