Trait
SNPs associated with Osteoarthritis, Knee, Total Knee Arthroplasty
88 genetic variants across 33 genes have been associated with Osteoarthritis, Knee, Total Knee Arthroplasty in published research. Key genes include AP3D1, APOC1, BNC2.
Associated variants88 total
| rsid | Gene | Effect | Evidence |
|---|---|---|---|
| rs11731421 | — | GWAS association (p=2.0e-32) | Large GWAS |
| rs224333 | GDF5 | GWAS association (p=8.0e-31) | Large GWAS |
| rs12509303 | — | GWAS association (p=7.0e-25) | Large GWAS |
| rs12310519 | — | GWAS association (p=1.0e-23) | Large GWAS |
| rs1558902 | FTO | GWAS association (p=7.0e-21) | Large GWAS |
| rs4523957 | SMG6 | GWAS association (p=2.0e-20) | Large GWAS |
| rs1078301 | LOC105376225 | GWAS association (p=9.0e-20) | Large GWAS |
| rs57908212 | AP3D1 | GWAS association (p=1.0e-19) | Large GWAS |
| rs876122 | — | GWAS association (p=9.0e-19) | Large GWAS |
| rs10131337 | — | GWAS association (p=2.0e-17) | Large GWAS |
| rs7184994 | — | GWAS association (p=4.0e-16) | Large GWAS |
| rs2899611 | — | GWAS association (p=3.0e-15) | Large GWAS |
| rs6488868 | — | GWAS association (p=3.0e-15) | Large GWAS |
| rs148024643 | SNRPC | GWAS association (p=3.0e-15) | Large GWAS |
| rs72732987 | — | GWAS association (p=9.0e-15) | Large GWAS |
| rs2747063 | — | GWAS association (p=1.0e-14) | Large GWAS |
| rs10408721 | — | GWAS association (p=6.0e-14) | Large GWAS |
| rs1292504 | — | GWAS association (p=1.0e-13) | Large GWAS |
| rs79309042 | — | GWAS association (p=1.0e-13) | Large GWAS |
| rs10807138 | — | GWAS association (p=2.0e-13) | Large GWAS |
| rs7181536 | USP8 | GWAS association (p=2.0e-13) | Large GWAS |
| rs7754762 | ESR1 | GWAS association (p=7.0e-13) | Large GWAS |
| rs62070652 | — | GWAS association (p=9.0e-13) | Large GWAS |
| rs3755381 | TGFA | GWAS association (p=1.0e-12) | Large GWAS |
| rs9533090 | — | GWAS association (p=1.0e-12) | Large GWAS |
| rs6894139 | MEF2C-AS1 | GWAS association (p=2.0e-12) | Large GWAS |
| rs998584 | POLR1C | GWAS association (p=4.0e-12) | Large GWAS |
| rs2110001 | LOC105375567 | GWAS association (p=5.0e-12) | Large GWAS |
| rs2061026 | — | GWAS association (p=6.0e-12) | Large GWAS |
| rs2521349 | MAP2K6 | GWAS association (p=6.0e-12) | Large GWAS |
| rs12925439 | ZNF469 | GWAS association (p=7.0e-12) | Large GWAS |
| rs75621460 | — | GWAS association (p=7.0e-12) | Large GWAS |
| rs552086 | DYM | GWAS association (p=1.0e-11) | Large GWAS |
| rs7925720 | CAND1.11 | GWAS association (p=1.0e-11) | Large GWAS |
| rs10076308 | SPRY4-AS1 | GWAS association (p=2.0e-11) | Large GWAS |
| rs6124883 | — | GWAS association (p=2.0e-11) | Large GWAS |
| rs2171126 | — | GWAS association (p=2.0e-11) | Large GWAS |
| rs1923409 | — | GWAS association (p=3.0e-11) | Large GWAS |
| rs4073717 | — | GWAS association (p=4.0e-11) | Large GWAS |
| rs2058744 | — | GWAS association (p=4.0e-11) | Large GWAS |
| rs17608747 | — | GWAS association (p=6.0e-11) | Large GWAS |
| rs2384145 | DNMT3A | GWAS association (p=6.0e-11) | Large GWAS |
| rs1440286 | TEAD1 | GWAS association (p=7.0e-11) | Large GWAS |
| rs17731453 | TBX5 | GWAS association (p=8.0e-11) | Large GWAS |
| rs10971930 | DCAF12 | GWAS association (p=1.0e-10) | Large GWAS |
| rs4776345 | SMAD3 | GWAS association (p=2.0e-10) | Large GWAS |
| rs61944841 | — | GWAS association (p=2.0e-10) | Large GWAS |
| rs2137235 | — | GWAS association (p=2.0e-10) | Large GWAS |
| rs7187586 | — | GWAS association (p=2.0e-10) | Large GWAS |
| rs11627050 | — | GWAS association (p=3.0e-10) | Large GWAS |
| rs12721051 | APOC1 | GWAS association (p=4.0e-10) | Large GWAS |
| rs1340098 | — | GWAS association (p=4.0e-10) | Large GWAS |
| rs1426371 | WSCD2 | GWAS association (p=4.0e-10) | Large GWAS |
| rs1552916 | PAM | GWAS association (p=4.0e-10) | Large GWAS |
| rs2076545 | — | GWAS association (p=4.0e-10) | Large GWAS |
| rs9907379 | — | GWAS association (p=4.0e-10) | Large GWAS |
| rs10501839 | — | GWAS association (p=6.0e-10) | Large GWAS |
| rs10810601 | BNC2 | GWAS association (p=6.0e-10) | Large GWAS |
| rs7608050 | — | GWAS association (p=6.0e-10) | Large GWAS |
| rs1447132 | — | GWAS association (p=8.0e-10) | Large GWAS |
| rs2334915 | — | GWAS association (p=8.0e-10) | Large GWAS |
| rs112153300 | COL6A2 | GWAS association (p=9.0e-10) | Large GWAS |
| rs2738293 | — | GWAS association (p=9.0e-10) | Large GWAS |
| rs28446722 | — | GWAS association (p=1.0e-09) | Large GWAS |
| rs4425336 | FAM13A | GWAS association (p=1.0e-09) | Large GWAS |
| rs12967215 | — | GWAS association (p=1.0e-09) | Large GWAS |
| rs1913707 | — | GWAS association (p=1.0e-09) | Large GWAS |
| rs10832027 | — | GWAS association (p=2.0e-09) | Large GWAS |
| rs3116961 | — | GWAS association (p=2.0e-09) | Large GWAS |
| rs6010675 | — | GWAS association (p=2.0e-09) | Large GWAS |
| rs146939415 | CYP19A1 | GWAS association (p=2.0e-09) | Large GWAS |
| rs72799248 | — | GWAS association (p=2.0e-09) | Large GWAS |
| rs1059698 | — | GWAS association (p=3.0e-09) | Large GWAS |
| rs12046459 | PMVK | GWAS association (p=3.0e-09) | Large GWAS |
| rs7719125 | — | GWAS association (p=3.0e-09) | Large GWAS |
| rs957512 | — | GWAS association (p=3.0e-09) | Large GWAS |
| rs11757152 | LOC107986619 | GWAS association (p=4.0e-09) | Large GWAS |
| rs4727295 | DTX2P1-UPK3BP1-PMS2P11 | GWAS association (p=6.0e-09) | Large GWAS |
| rs4764131 | — | GWAS association (p=6.0e-09) | Large GWAS |
| rs10048976 | LOC105374264 | GWAS association (p=7.0e-09) | Large GWAS |
| rs2454477 | — | GWAS association (p=7.0e-09) | Large GWAS |
| rs12764568 | — | GWAS association (p=9.0e-09) | Large GWAS |
| rs2637262 | — | GWAS association (p=1.0e-08) | Large GWAS |
| rs4886649 | — | GWAS association (p=1.0e-08) | Large GWAS |
| rs4959613 | — | GWAS association (p=1.0e-08) | Large GWAS |
| rs1935454 | — | GWAS association (p=1.0e-08) | Large GWAS |
| rs911610 | — | GWAS association (p=1.0e-08) | Large GWAS |
| rs9884482 | — | GWAS association (p=1.0e-08) | Large GWAS |
Associations aggregated from the GWAS Catalog and curated literature. Informational only — not medical advice.