rs12310519
▶GWAS Catalog Trait Associations (3)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
GWAS Catalog Trait Associations (3)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
osteoarthritis, knee
Hatzikotoulas K et al. “Translational genomics of osteoarthritis in 1,962,069 individuals.” Nature 641(8065):1217-1224 (2025)
Allele T
OR 1.06
p 1.0e-25
N 1,316,500
Large GWAS
multi-ancestry
Henkel C et al. “Genome-wide association meta-analysis of knee and hip osteoarthritis uncovers genetic differences between patients treated with joint replacement and patients without joint replacement.” Annals of the Rheumatic Diseases 82(3):384-392 (2023)
Allele T
OR 1.11
p 1.0e-13
N 661,143
Meta-analysisLarge GWAS
European
osteoarthritis, knee, total knee arthroplasty
Hatzikotoulas K et al. “Translational genomics of osteoarthritis in 1,962,069 individuals.” Nature 641(8065):1217-1224 (2025)
Allele T
OR 1.10
p 1.0e-23
N 1,006,624
Large GWAS
multi-ancestry
Back pain
Bjornsdottir G et al. “Rare SLC13A1 variants associate with intervertebral disc disorder highlighting role of sulfate in disc pathology.” Nature Communications 13(1):634 (2022)
Allele T
OR 1.04
p 3.0e-8
N 1,028,957
Large GWAS
European
Freidin MB et al. “Insight into the genetic architecture of back pain and its risk factors from a study of 509,000 individuals.” Pain 160(6):1361-1373 (2019)
Allele T
OR 0.06
p 1.0e-14
N 350,000
Large GWAS
multi-ancestry
Suri P et al. “Genome-wide meta-analysis of 158,000 individuals of European ancestry identifies three loci associated with chronic back pain.” Plos Genetics 14(9):e1007601 (2018)
Allele T
OR 1.07
p 5.0e-19
N 158,025
Meta-analysisLarge GWAS
European
This variant is in our database but has no known associations or PRS memberships yet.
Gene information from NCBI Gene. Variant classifications from ClinVar.
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