rs75621460

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GWAS Catalog Trait Associations (7)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

osteoarthritis

Hatzikotoulas K et al. “Translational genomics of osteoarthritis in 1,962,069 individuals.” Nature 641(8065):1217-1224 (2025)
Allele A
OR 1.09
p 1.0e-16
N 1,962,069
Large GWAS
multi-ancestry
McDonald MN et al. “Novel genetic loci associated with osteoarthritis in multi-ancestry analyses in the Million Veteran Program and UK Biobank.” Nature Genetics 54(12):1816-1826 (2022)
Allele A
OR 1.02
p 6.0e-10
N 2,421,870
Major Consortium StudyLarge GWAS
European, South Asian, East Asian, African unspecified, Hispanic or Latin American
Tachmazidou I et al. “Identification of new therapeutic targets for osteoarthritis through genome-wide analyses of UK Biobank data.” Nature Genetics 51(2):230-236 (2019)
Allele A
OR 1.16
p 2.0e-15
N 455,221
Major Consortium StudyLarge GWAS
European

osteoarthritis, hip, osteoarthritis, knee, total joint arthroplasty

Hatzikotoulas K et al. “Translational genomics of osteoarthritis in 1,962,069 individuals.” Nature 641(8065):1217-1224 (2025)
Allele A
OR 1.18
p 2.0e-16
N 866,417
Large GWAS
multi-ancestry
Boer CG et al. “Deciphering osteoarthritis genetics across 826,690 individuals from 9 populations.” Cell 184(18):4784-4818.e17 (2021)
Allele A
OR 1.21
p 3.0e-10
N 368,576
Large GWAS
European

osteoarthritis, hip, total hip arthroplasty

Hatzikotoulas K et al. “Translational genomics of osteoarthritis in 1,962,069 individuals.” Nature 641(8065):1217-1224 (2025)
Allele A
OR 1.19
p 9.0e-13
N 1,031,046
Large GWAS
multi-ancestry

osteoarthritis, hip

Hatzikotoulas K et al. “Translational genomics of osteoarthritis in 1,962,069 individuals.” Nature 641(8065):1217-1224 (2025)
Allele A
OR 1.14
p 2.0e-12
N 1,152,707
Large GWAS
multi-ancestry

osteoarthritis, hip, osteoarthritis, knee

Hatzikotoulas K et al. “Translational genomics of osteoarthritis in 1,962,069 individuals.” Nature 641(8065):1217-1224 (2025)
Allele A
OR 1.10
p 3.0e-12
N 1,294,321
Large GWAS
multi-ancestry
Tachmazidou I et al. “Identification of new therapeutic targets for osteoarthritis through genome-wide analyses of UK Biobank data.” Nature Genetics 51(2):230-236 (2019)
Allele A
OR 1.16
p 3.0e-9
N 417,596
Major Consortium StudyLarge GWAS
European

osteoarthritis, knee

Hollis B et al. “Lifetime risk and genetic predisposition to post-traumatic OA of the knee in the UK Biobank.” Osteoarthritis and Cartilage 31(10):1377-1387 (2023)
Allele A
OR 1.14
p 6.0e-12
N 354,561
Major Consortium StudyLarge GWAS
European
Hatzikotoulas K et al. “Translational genomics of osteoarthritis in 1,962,069 individuals.” Nature 641(8065):1217-1224 (2025)
Allele A
OR 1.10
p 3.0e-9
N 1,316,500
Large GWAS
multi-ancestry

osteoarthritis, knee, total knee arthroplasty

Hatzikotoulas K et al. “Translational genomics of osteoarthritis in 1,962,069 individuals.” Nature 641(8065):1217-1224 (2025)
Allele A
OR 1.19
p 7.0e-12
N 1,006,624
Large GWAS
multi-ancestry

This variant is in our database but has no known associations or PRS memberships yet.

Gene information from NCBI Gene. Variant classifications from ClinVar.

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