Trait
SNPs associated with Osteoarthritis Risk
267 genetic variants across 73 genes have been associated with Osteoarthritis Risk in published research. Key genes include ALDH1A2, APOE, ARNTL.
Associated variants267 total
| rsid | Gene | Effect | Evidence |
|---|---|---|---|
| rs6094710 | — | GWAS association (p=2.0e-10) | Meta-analysis |
| rs3757837 | CAMK2B | GWAS association (p=8.0e-10) | Meta-analysis |
| rs143383 | GDF5 | Higher risk of knee and hand osteoarthritis | Meta-analysis |
| rs3755380 | TGFA | GWAS association (p=1.0e-37) | Major Consortium Study |
| rs13107325 | SLC39A8 | GWAS association (p=6.0e-35) | Major Consortium Study |
| rs6855246 | — | GWAS association (p=5.0e-29) | Major Consortium Study |
| rs35225200 | — | GWAS association (p=1.0e-26) | Major Consortium Study |
| rs75621460 | — | GWAS association (p=1.0e-16) | Major Consortium Study |
| rs3771501 | TGFA | GWAS association (p=4.0e-16) | Major Consortium Study |
| rs3911078 | TGFA | GWAS association (p=2.0e-15) | Major Consortium Study |
| rs6511707 | — | GWAS association (p=2.0e-15) | Major Consortium Study |
| rs919642 | — | GWAS association (p=9.0e-15) | Major Consortium Study |
| rs10974438 | — | GWAS association (p=1.0e-14) | Major Consortium Study |
| rs2248393 | UQCC1 | GWAS association (p=4.0e-14) | Major Consortium Study |
| rs11085743 | — | GWAS association (p=9.0e-14) | Major Consortium Study |
| rs1560707 | — | GWAS association (p=1.0e-13) | Major Consortium Study |
| rs2396724 | — | GWAS association (p=1.0e-13) | Major Consortium Study |
| rs55872725 | FTO | GWAS association (p=2.0e-13) | Major Consortium Study |
| rs2061027 | LTBP1 | GWAS association (p=3.0e-13) | Major Consortium Study |
| rs9284010 | IKBKB | GWAS association (p=5.0e-13) | Major Consortium Study |
| rs1975161 | — | GWAS association (p=7.0e-13) | Major Consortium Study |
| rs7903146 | TCF7L2 | GWAS association (p=8.0e-13) | Major Consortium Study |
| rs35206230 | — | GWAS association (p=1.0e-12) | Major Consortium Study |
| rs11409738 | — | GWAS association (p=8.0e-12) | Major Consortium Study |
| rs2622873 | — | GWAS association (p=1.0e-11) | Major Consortium Study |
| rs7953929 | — | GWAS association (p=1.0e-11) | Major Consortium Study |
| rs8180817 | — | GWAS association (p=1.0e-11) | Major Consortium Study |
| rs1421085 | FTO | GWAS association (p=1.0e-11) | Major Consortium Study |
| rs330050 | — | GWAS association (p=2.0e-11) | Major Consortium Study |
| rs2294097 | IKBKB | GWAS association (p=3.0e-11) | Major Consortium Study |
| rs557675 | — | GWAS association (p=5.0e-11) | Major Consortium Study |
| rs62262139 | RBM6 | GWAS association (p=9.0e-11) | Major Consortium Study |
| rs2043195 | — | GWAS association (p=1.0e-10) | Major Consortium Study |
| rs1126464 | — | GWAS association (p=2.0e-10) | Major Consortium Study |
| rs34811474 | — | GWAS association (p=2.0e-10) | Major Consortium Study |
| rs1897112 | EFEMP1 | GWAS association (p=2.0e-10) | Major Consortium Study |
| rs113907280 | — | GWAS association (p=2.0e-10) | Major Consortium Study |
| rs1913707 | — | GWAS association (p=3.0e-10) | Major Consortium Study |
| rs13105682 | — | GWAS association (p=5.0e-10) | Major Consortium Study |
| rs4790310 | — | GWAS association (p=5.0e-10) | Major Consortium Study |
| rs1149620 | — | GWAS association (p=7.0e-10) | Major Consortium Study |
| rs2171126 | — | GWAS association (p=9.0e-10) | Major Consortium Study |
| rs67542687 | — | GWAS association (p=9.0e-10) | Major Consortium Study |
| rs2856821 | HLA-DPA1 | GWAS association (p=1.0e-09) | Major Consortium Study |
| rs4714791 | — | GWAS association (p=1.0e-09) | Major Consortium Study |
| rs4757145 | — | GWAS association (p=1.0e-09) | Major Consortium Study |
| rs2820436 | LYPLAL1-AS1 | GWAS association (p=2.0e-09) | Major Consortium Study |
| rs62182810 | — | GWAS association (p=2.0e-09) | Major Consortium Study |
| rs2785988 | — | GWAS association (p=2.0e-09) | Major Consortium Study |
| rs10502437 | — | GWAS association (p=2.0e-09) | Major Consortium Study |
| rs798726 | — | GWAS association (p=2.0e-09) | Major Consortium Study |
| rs11732213 | SLBP | GWAS association (p=3.0e-09) | Major Consortium Study |
| rs3129200 | COL11A2 | GWAS association (p=4.0e-09) | Major Consortium Study |
| rs115740542 | — | GWAS association (p=5.0e-09) | Major Consortium Study |
| rs2886521 | — | GWAS association (p=6.0e-09) | Major Consortium Study |
| rs10654220 | — | GWAS association (p=7.0e-09) | Major Consortium Study |
| rs76045294 | — | GWAS association (p=8.0e-09) | Major Consortium Study |
| rs4651103 | RABGAP1L | GWAS association (p=9.0e-09) | Major Consortium Study |
| rs11031191 | — | GWAS association (p=1.0e-08) | Major Consortium Study |
| rs10218792 | — | GWAS association (p=2.0e-08) | Major Consortium Study |
| rs317630 | CPSF6 | GWAS association (p=2.0e-08) | Major Consortium Study |
| rs547116051 | — | GWAS association (p=2.0e-08) | Major Consortium Study |
| rs528981060 | SCUBE1 | GWAS association (p=2.0e-08) | Major Consortium Study |
| rs72855791 | — | GWAS association (p=2.0e-08) | Major Consortium Study |
| rs6793528 | RBM6 | GWAS association (p=2.0e-08) | Major Consortium Study |
| rs61427182 | XKR6 | GWAS association (p=2.0e-08) | Major Consortium Study |
| rs10896164 | GRK2 | GWAS association (p=2.0e-08) | Major Consortium Study |
| rs12154055 | — | GWAS association (p=3.0e-08) | Major Consortium Study |
| rs2299285 | — | GWAS association (p=3.0e-08) | Major Consortium Study |
| rs6572663 | — | GWAS association (p=4.0e-08) | Major Consortium Study |
| rs13140486 | LOC105377621 | GWAS association (p=5.0e-08) | Major Consortium Study |
| rs2842572 | SENP6 | GWAS association (p=5.0e-08) | Major Consortium Study |
| rs7561547 | TGFA | GWAS association (p=2.0e-13) | Major Consortium Study |
| rs12509303 | — | GWAS association (p=4.0e-28) | Large GWAS |
| rs3910146 | LOC124900668 | GWAS association (p=2.0e-27) | Large GWAS |
| rs11731421 | — | GWAS association (p=5.0e-27) | Large GWAS |
| rs981819 | UQCC1 | GWAS association (p=6.0e-25) | Large GWAS |
| rs9930333 | FTO | GWAS association (p=2.0e-24) | Large GWAS |
| rs429358 | APOE | GWAS association (p=2.0e-22) | Large GWAS |
| rs28579874 | — | GWAS association (p=2.0e-21) | Large GWAS |
| rs10416125 | — | GWAS association (p=6.0e-21) | Large GWAS |
| rs11719514 | PBRM1 | GWAS association (p=1.0e-20) | Large GWAS |
| rs4979341 | — | GWAS association (p=3.0e-18) | Large GWAS |
| rs10953758 | FOXP2 | GWAS association (p=3.0e-18) | Large GWAS |
| rs2824183 | — | GWAS association (p=3.0e-18) | Large GWAS |
| rs4098282 | — | GWAS association (p=9.0e-18) | Large GWAS |
| rs11831278 | — | GWAS association (p=1.0e-17) | Large GWAS |
| rs34695471 | — | GWAS association (p=2.0e-17) | Large GWAS |
| rs8073455 | — | GWAS association (p=8.0e-17) | Large GWAS |
| rs4776880 | — | GWAS association (p=1.0e-16) | Large GWAS |
| rs7953280 | — | GWAS association (p=2.0e-16) | Large GWAS |
| rs6928965 | — | GWAS association (p=8.0e-16) | Large GWAS |
| rs4545055 | — | GWAS association (p=1.0e-15) | Large GWAS |
| rs7223535 | — | GWAS association (p=3.0e-15) | Large GWAS |
| rs7538503 | — | GWAS association (p=3.0e-15) | Large GWAS |
| rs9462027 | — | GWAS association (p=7.0e-15) | Large GWAS |
| rs11726937 | PRDM5 | GWAS association (p=7.0e-15) | Large GWAS |
| rs55925606 | — | GWAS association (p=1.0e-14) | Large GWAS |
| rs7036975 | — | GWAS association (p=2.0e-14) | Large GWAS |
| rs56283067 | — | GWAS association (p=2.0e-14) | Large GWAS |
Showing the top 100 of 267 variants by evidence strength.
Associations aggregated from the GWAS Catalog and curated literature. Informational only — not medical advice.