rs11732213

This is a intron variant variant in the SLBP gene.

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GWAS Catalog Trait Associations (3)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

osteoarthritis, hip

Hatzikotoulas K et al. “Translational genomics of osteoarthritis in 1,962,069 individuals.” Nature 641(8065):1217-1224 (2025)
Allele T
OR 1.07
p 7.0e-22
N 1,152,707
Large GWAS
multi-ancestry

osteoarthritis, hip, osteoarthritis, knee

Tachmazidou I et al. “Identification of new therapeutic targets for osteoarthritis through genome-wide analyses of UK Biobank data.” Nature Genetics 51(2):230-236 (2019)
Allele T
OR 1.06
p 9.0e-10
N 417,596
Major Consortium StudyLarge GWAS
European

osteoarthritis

McDonald MN et al. “Novel genetic loci associated with osteoarthritis in multi-ancestry analyses in the Million Veteran Program and UK Biobank.” Nature Genetics 54(12):1816-1826 (2022)
Allele T
OR 1.01
p 3.0e-9
N 2,421,870
Major Consortium StudyLarge GWAS
European, South Asian, East Asian, African unspecified, Hispanic or Latin American

About SLBP

This gene encodes a protein that binds to the stem-loop structure in replication-dependent histone mRNAs. Histone mRNAs do not contain introns or polyadenylation signals, and are processed by endonucleolytic cleavage. The stem-loop structure is essential for efficient processing but this structure also controls the transport, translation and stability of histone mRNAs. Expression of the protein is regulated during the cell cycle, increasing more than 10-fold during the latter part of G1. [provided by RefSeq, Jul 2008]

View all SLBP variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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