SLBP
stem-loop histone mRNA binding protein
Summary
This gene encodes a protein that binds to the stem-loop structure in replication-dependent histone mRNAs. Histone mRNAs do not contain introns or polyadenylation signals, and are processed by endonucleolytic cleavage. The stem-loop structure is essential for efficient processing but this structure also controls the transport, translation and stability of histone mRNAs. Expression of the protein is regulated during the cell cycle, increasing more than 10-fold during the latter part of G1. [provided by RefSeq, Jul 2008]
Known Variants17 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs1716001420 | 4:1,695,425 | T/A | — | uncertain significance |
| rs2546682827 | 4:1,696,554 | G/A | — | uncertain significance |
| rs2546684010 | 4:1,697,962 | G/A | — | uncertain significance |
| rs752458560 | 4:1,698,019 | C/G | — | uncertain significance |
| rs1288581114 | 4:1,698,041 | T/C | — | uncertain significance |
| rs2247341 | 4:1,701,317 | G/A | synonymous variant | — |
| rs1716250497 | 4:1,701,386 | A/C | — | likely benign |
| rs1307886229 | 4:1,701,781 | G/C | — | uncertain significance |
| rs11732213 | 4:1,704,244 | T/C | intron variant | — |
| rs778593556 | 4:1,705,365 | T/C | — | uncertain significance |
| rs751873933 | 4:1,705,398 | C/T | — | uncertain significance |
| rs2592831 | 4:1,711,404 | T/A | — | — |
| rs78364480 | 4:1,711,776 | G/C | — | — |
| rs2051514 | 4:1,712,968 | A/C | — | — |
| rs1454397473 | 4:1,713,626 | G/A | — | uncertain significance |
| rs1294338570 | 4:1,713,686 | G/C | — | uncertain significance |
| rs1020435422 | 4:1,713,893 | G/A | — | uncertain significance |
Gene information from NCBI Gene. Variant classifications from ClinVar.