rs557675
▶GWAS Catalog Trait Associations (11)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
GWAS Catalog Trait Associations (11)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
hypertension
Loya H et al. “A scalable variational inference approach for increased mixed-model association power.” Nature Genetics 57(2):461-468 (2025)
Allele G
OR 0.04
p 8.0e-18
N 394,626
Large GWAS
European
esterified cholesterol measurement
Zoodsma M et al. “A genetic map of human metabolism across the allele frequency spectrum.” Nature Genetics 57(10):2445-2455 (2025)
Allele G
OR 0.01
p 3.0e-13
N 450,015
Large GWAS
multi-ancestry
apolipoprotein A 1 measurement
Richardson TG et al. “Evaluating the relationship between circulating lipoprotein lipids and apolipoproteins with risk of coronary heart disease: A multivariable Mendelian randomisation analysis.” Plos Medicine 17(3):e1003062 (2020)
Allele T
OR 0.01
p 2.0e-12
N 393,193
Large GWAS
European
total cholesterol measurement
Zoodsma M et al. “A genetic map of human metabolism across the allele frequency spectrum.” Nature Genetics 57(10):2445-2455 (2025)
Allele G
OR 0.01
p 2.0e-12
N 450,015
Large GWAS
multi-ancestry
Graham SE et al. “The power of genetic diversity in genome-wide association studies of lipids.” Nature 600(7890):675-679 (2021)
Allele G
OR 0.01
p 6.0e-10
N 1,320,016
Large GWAS
European
atopic eczema
Chen Y et al. “Genome-Wide Integration of Genetic and Genomic Studies of Atopic Dermatitis: Insights into Genetic Architecture and Pathogenesis.” The Journal of Investigative Dermatology 142(11):2958-2967.e8 (2022)
Allele T
OR 0.06
p 3.0e-12
N 837,496
Large GWAS
multi-ancestry
osteoarthritis
Hatzikotoulas K et al. “Translational genomics of osteoarthritis in 1,962,069 individuals.” Nature 641(8065):1217-1224 (2025)
Allele T
OR 1.02
p 5.0e-11
N 1,962,069
Large GWAS
multi-ancestry
McDonald MN et al. “Novel genetic loci associated with osteoarthritis in multi-ancestry analyses in the Million Veteran Program and UK Biobank.” Nature Genetics 54(12):1816-1826 (2022)
Allele T
OR 1.00
p 5.0e-8
N 2,421,870
Major Consortium StudyLarge GWAS
European, South Asian, East Asian, African unspecified, Hispanic or Latin American
free cholesterol measurement
Zoodsma M et al. “A genetic map of human metabolism across the allele frequency spectrum.” Nature Genetics 57(10):2445-2455 (2025)
Allele G
OR 0.01
p 2.0e-10
N 450,015
Large GWAS
multi-ancestry
myocardial infarction
Sakaue S et al. “A cross-population atlas of genetic associations for 220 human phenotypes.” Nature Genetics 53(10):1415-1424 (2021)
Allele G
OR 0.05
p 6.0e-9
N 623,029
Large GWAS
multi-ancestry
osteoarthritis, knee
Hollis B et al. “Lifetime risk and genetic predisposition to post-traumatic OA of the knee in the UK Biobank.” Osteoarthritis and Cartilage 31(10):1377-1387 (2023)
Allele G
OR 0.97
p 6.0e-9
N 354,561
Major Consortium StudyLarge GWAS
European
educational attainment
Okbay A et al. “Polygenic prediction of educational attainment within and between families from genome-wide association analyses in 3 million individuals.” Nature Genetics 54(4):437-449 (2022)
Allele T
OR 0.01
p 1.0e-8
N 3,037,499
Large GWAS
European
This variant is in our database but has no known associations or PRS memberships yet.
Gene information from NCBI Gene. Variant classifications from ClinVar.
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