rs8180817

▶

GWAS Catalog Trait Associations (6)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

insomnia

Watanabe K et al. “Genome-wide meta-analysis of insomnia prioritizes genes associated with metabolic and psychiatric pathways.” Nature Genetics 54(8):1125-1132 (2022)
Allele C
OR 0.01
p 1.0e-23
N 2,365,010
Meta-analysisLarge GWAS
European
Song W et al. “Genome-wide association analysis of insomnia using data from Partners Biobank.” Scientific Reports 10(1):6928 (2020)
Allele C
OR —
p 2.0e-8
N 422,239
Large GWAS
multi-ancestry

insomnia measurement

Jansen PR et al. “Genome-wide analysis of insomnia in 1,331,010 individuals identifies new risk loci and functional pathways.” Nature Genetics 51(3):394-403 (2019)
Allele G
OR 1.05
p 2.0e-16
N 1,331,010
Large GWAS
European

osteoarthritis

Verma A et al. “Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.” Science (new York, N.y.) 385(6706):eadj1182 (2024)
Allele G
OR 0.03
p 1.0e-11
N 567,064
Major Consortium StudyLarge GWAS
multi-ancestry

major depressive disorder

Als TD et al. “Depression pathophysiology, risk prediction of recurrence and comorbid psychiatric disorders using genome-wide analyses.” Nature Medicine 29(7):1832-1844 (2023)
Allele G
OR 0.02
p 2.0e-11
N 1,349,887
Large GWAS
European

anxiety disorder

Friligkou E et al. “Gene discovery and biological insights into anxiety disorders from a large-scale multi-ancestry genome-wide association study.” Nature Genetics 56(10):2036-2045 (2024)
Allele G
OR —
β 0.012
p 4.0e-9
N 1,096,458
Large GWAS
European

body height

Schoeler T et al. “Participation bias in the UK Biobank distorts genetic associations and downstream analyses.” Nature Human Behaviour 7(7):1216-1227 (2023)
Allele C
OR 0.10
p 3.0e-8
N 283,749
Major Consortium StudyLarge GWAS
European

This variant is in our database but has no known associations or PRS memberships yet.

Gene information from NCBI Gene. Variant classifications from ClinVar.

Community Wiki

No community notes yet for this variant. Sign in to start one.

Comments

Sign in to join the discussion.

Loading comments…