rs2820436

This variant is located in the LYPLAL1-AS1 gene.

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GWAS Catalog Trait Associations (9)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

BMI-adjusted waist-hip ratio

Graff M et al. “Genome-wide physical activity interactions in adiposity - A meta-analysis of 200,452 adults.” Plos Genetics 13(4):e1006528 (2017)
Allele C
OR 0.06
p 2.0e-21
N 118,949
Meta-analysisLarge GWAS
multi-ancestry

osteoarthritis, hip, body mass index

Zhang L et al. “A sex- and site-specific relationship between body mass index and osteoarthritis: evidence from observational and genetic analyses.” Osteoarthritis and Cartilage 31(6):819-828 (2023)
Allele A
OR —
p 2.0e-15
N 1,160,222
Large GWAS
European

Umbilical hernia

Wei J et al. “Identification of fifty-seven novel loci for abdominal wall hernia development and their biological and clinical implications: results from the UK Biobank.” Hernia : the Journal of Hernias and Abdominal Wall Surgery 26(1):335-348 (2022)
Allele A
OR 1.20
p 3.0e-15
N 275,546
Major Consortium StudyLarge GWAS
European

osteoarthritis

Zengini E et al. “Genome-wide analyses using UK Biobank data provide insights into the genetic architecture of osteoarthritis.” Nature Genetics 50(4):549-558 (2018)
Allele A
OR 1.07
p 2.0e-9
N 50,508
Major Consortium StudyLarge GWAS
European

blood insulin amount

Lagou V et al. “Sex-dimorphic genetic effects and novel loci for fasting glucose and insulin variability.” Nature Communications 12(1):24 (2021)
Allele C
OR 0.02
p 4.0e-9
N 98,210
Large GWAS
European

Inguinal hernia

Wei J et al. “Identification of fifty-seven novel loci for abdominal wall hernia development and their biological and clinical implications: results from the UK Biobank.” Hernia : the Journal of Hernias and Abdominal Wall Surgery 26(1):335-348 (2022)
Allele A
OR 1.07
p 5.0e-9
N 275,546
Major Consortium StudyLarge GWAS
European

osteoarthritis, hip, osteoarthritis, knee

Zengini E et al. “Genome-wide analyses using UK Biobank data provide insights into the genetic architecture of osteoarthritis.” Nature Genetics 50(4):549-558 (2018)
Allele A
OR 1.08
p 2.0e-8
N 32,970
Major Consortium StudyLarge GWAS
European

body mass index

Gong J et al. “Trans-ethnic analysis of metabochip data identifies two new loci associated with BMI.” International Journal of Obesity (2005) 42(3):384-390 (2018)
Allele A
OR 0.00
p 4.0e-8
N 102,514
Large GWAS
multi-ancestry

BMI-adjusted waist-hip ratio, physical activity measurement

Graff M et al. “Genome-wide physical activity interactions in adiposity - A meta-analysis of 200,452 adults.” Plos Genetics 13(4):e1006528 (2017)
Allele C
OR 0.06
p 3.0e-27
N 156,653
Meta-analysisLarge GWAS
multi-ancestry

This variant is in our database but has no known associations or PRS memberships yet.

Gene information from NCBI Gene. Variant classifications from ClinVar.

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