rs72760655

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GWAS Catalog Trait Associations (3)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

birth weight, parental genotype effect measurement

Warrington NM et al. “Maternal and fetal genetic effects on birth weight and their relevance to cardio-metabolic risk factors.” Nature Genetics 51(5):804-814 (2019)

Allele C

OR 0.03

p 4.0e-15

N 230,069

Large GWAS

European

osteoarthritis, knee

Henkel C et al. “Genome-wide association meta-analysis of knee and hip osteoarthritis uncovers genetic differences between patients treated with joint replacement and patients without joint replacement.” Annals of the Rheumatic Diseases 82(3):384-392 (2023)

Allele A

OR 1.09

p 1.0e-14

N 661,143

Meta-analysisLarge GWAS

European

Kulm S et al. “Characterization of Genetic Risk of End-Stage Knee Osteoarthritis Treated with Total Knee Arthroplasty: A Genome-Wide Association Study.” The Journal of Bone and Joint Surgery. American Volume 104(20):1814-1820 (2022)

Allele A

OR 1.10

p 4.0e-14

N 389,548

Large GWAS

European

osteoarthritis, hip, osteoarthritis, knee

Boer CG et al. “Deciphering osteoarthritis genetics across 826,690 individuals from 9 populations.” Cell 184(18):4784-4818.e17 (2021)

Allele A

OR 1.05

p 6.0e-13

N 490,345

Large GWAS

multi-ancestry

This variant is in our database but has no known associations or PRS memberships yet.

Gene information from NCBI Gene. Variant classifications from ClinVar.

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