rs1790132

This variant is located in the MPHOSPH9 gene.

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GWAS Catalog Trait Associations (2)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

osteoarthritis, knee

Henkel C et al. “Genome-wide association meta-analysis of knee and hip osteoarthritis uncovers genetic differences between patients treated with joint replacement and patients without joint replacement.” Annals of the Rheumatic Diseases 82(3):384-392 (2023)

Allele G

OR 0.92

p 3.0e-9

N 661,143

Meta-analysisLarge GWAS

European

uterine fibroid

Kim J et al. “Genome-wide meta-analysis identifies novel risk loci for uterine fibroids within and across multiple ancestry groups.” Nature Communications 16(1):2273 (2025)

Allele T

OR 0.09

p 4.0e-9

N 253,542

Meta-analysisLarge GWAS

East Asian, Central Asian, South Asian

About MPHOSPH9

Involved in negative regulation of cilium assembly. Located in Golgi apparatus; centriole; and centrosome. Implicated in multiple sclerosis. [provided by Alliance of Genome Resources, Jul 2025]

View all MPHOSPH9 variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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