H1-7
H1.7 linker histone
Summary
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-independent histone that is a member of the histone H1 family. The related mouse gene encodes a testis specific protein that is required for spermatogenesis and male fertility. [provided by RefSeq, Oct 2015]
Known Variants23 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs139361918 | 12:48,723,186 | A/G | — | uncertain significance |
| rs368782163 | 12:48,723,191 | G/C | — | uncertain significance |
| rs756117628 | 12:48,723,213 | G/A | — | uncertain significance |
| rs763519603 | 12:48,723,261 | T/A | — | uncertain significance |
| rs1952541827 | 12:48,723,292 | G/A | — | uncertain significance |
| rs2732441 | 12:48,723,324 | C/T | stop gained | — |
| rs1280196944 | 12:48,723,352 | A/T | — | uncertain significance |
| rs770163249 | 12:48,723,364 | A/C | — | uncertain significance |
| rs2498922661 | 12:48,723,424 | C/T | — | uncertain significance |
| rs769015376 | 12:48,723,447 | G/T | — | uncertain significance |
| rs1379727705 | 12:48,723,456 | C/T | — | uncertain significance |
| rs372471527 | 12:48,723,493 | G/A | — | uncertain significance |
| rs867635739 | 12:48,723,498 | C/G | — | uncertain significance |
| rs780366237 | 12:48,723,502 | C/A | — | uncertain significance |
| rs957723539 | 12:48,723,544 | G/A | — | uncertain significance |
| rs866380817 | 12:48,723,547 | G/A | — | uncertain significance |
| rs766464330 | 12:48,723,558 | C/T | — | uncertain significance |
| rs774944969 | 12:48,723,580 | G/A | — | uncertain significance |
| rs1189374029 | 12:48,723,622 | A/G | — | uncertain significance |
| rs371502487 | 12:48,723,778 | G/A | — | uncertain significance |
| rs748944960 | 12:48,723,780 | A/G | — | uncertain significance |
| rs764466546 | 12:48,723,822 | G/A | — | uncertain significance |
| rs774750125 | 12:48,723,825 | C/A | — | likely benign |
Gene information from NCBI Gene. Variant classifications from ClinVar.