rs10484578
▶GWAS Catalog Trait Associations (2)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
GWAS Catalog Trait Associations (2)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
osteoarthritis, hip, osteoarthritis, knee, total joint arthroplasty
systemic lupus erythematosus
▶Research that mentions this SNP (1)
▶Population admixture associated with disease prevalence in the Boston Puerto Rican health studyAssociationN=1,129Chao-Qiang Lai et al.(2009)· Human Genetics
This study examined whether genetic ancestry is associated with disease prevalence in the Boston Puerto Rican Health Study (N=1,129). Using 100 ancestry informative markers (AIMs), the authors estimated that the Puerto Rican population is 57.2% European, 27.4% African, and 15.4% Native American ancestry. African ancestry was negatively associated with type 2 diabetes (OR=0.33, 95% CI 0.13-0.84, P=0.021) and cardiovascular disease (OR=0.32, 95% CI 0.10-1.00, P=0.049), while positively associated with hypertension (OR=2.94, 95% CI 1.14-7.61, P=0.026). No significant association was found between ancestry and obesity or depression. The results demonstrate that population admixture can confound genetic association studies and that adjustment for ancestry is critical when ancestry is associated with disease.
This variant is in our database but has no known associations or PRS memberships yet.
Gene information from NCBI Gene. Variant classifications from ClinVar.
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