GSDMC
gasdermin C
Summary
Enables wide pore channel activity. Involved in pyroptotic inflammatory response. Located in cytoplasm. Is active in plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]
Known Variants46 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs10956487 | 8:130,717,716 | A/C | — | — |
| rs10808583 | 8:130,718,020 | G/A | intergenic variant | — |
| rs7833174 | 8:130,718,772 | T/G | — | — |
| rs7814941 | 8:130,718,859 | A/T | — | — |
| rs79164994 | 8:130,719,443 | A/G | — | — |
| rs7815955 | 8:130,719,567 | A/T | intergenic variant | — |
| rs7816342 | 8:130,719,623 | G/A | intergenic variant | — |
| rs7816131 | 8:130,719,718 | A/G | — | — |
| rs10087031 | 8:130,721,420 | T/C | — | — |
| rs116662391 | 8:130,721,421 | T/C | — | — |
| rs78923981 | 8:130,721,597 | C/T | regulatory region variant | — |
| rs113614614 | 8:130,721,753 | C/T | — | — |
| rs6470764 | 8:130,725,665 | C/G | — | — |
| rs4368942 | 8:130,729,518 | T/A | — | — |
| rs11984666 | 8:130,730,280 | C/G | — | — |
| rs4733727 | 8:130,731,484 | C/T | intergenic variant | — |
| rs4733728 | 8:130,731,563 | C/A | intergenic variant | — |
| rs7831774 | 8:130,732,740 | G/A | intergenic variant | — |
| rs28743107 | 8:130,735,662 | C/G | — | — |
| rs6470765 | 8:130,736,697 | A/T | — | — |
| rs3886937 | 8:130,737,391 | T/C | upstream gene variant | — |
| rs4733732 | 8:130,738,457 | C/T | regulatory region variant | — |
| rs7826493 | 8:130,738,972 | A/G | regulatory region variant | — |
| rs559128832 | 8:130,748,057 | C/A | — | — |
| rs201817415 | 8:130,760,803 | G/T | — | uncertain significance |
| rs773291879 | 8:130,762,238 | A/C | — | uncertain significance |
| rs2033111280 | 8:130,762,262 | A/G | — | uncertain significance |
| rs748924722 | 8:130,762,323 | C/T | — | likely benign |
| rs35085916 | 8:130,762,324 | A/G | — | benign |
| rs1444716047 | 8:130,762,334 | C/T | — | uncertain significance |
| rs2033142211 | 8:130,762,711 | C/G | — | uncertain significance |
| rs2033145062 | 8:130,762,744 | T/A | — | uncertain significance |
| rs373058778 | 8:130,763,808 | A/G | — | uncertain significance |
| rs770331372 | 8:130,764,132 | C/T | — | uncertain significance |
| rs79763318 | 8:130,765,029 | C/T | — | benign |
| rs769904707 | 8:130,772,802 | G/C | — | uncertain significance |
| rs200990251 | 8:130,774,937 | G/T | — | uncertain significance |
| rs201826548 | 8:130,777,944 | T/C | — | likely benign |
| rs16904151 | 8:130,777,995 | C/T | — | benign |
| rs750958886 | 8:130,788,481 | G/C | — | uncertain significance |
| rs143364779 | 8:130,789,673 | T/C | — | uncertain significance |
| rs35919954 | 8:130,789,674 | C/T | — | benign |
| rs1490410688 | 8:130,789,701 | A/T | — | uncertain significance |
| rs754298748 | 8:130,789,715 | C/T | — | uncertain significance |
| rs371192399 | 8:130,789,736 | A/G | — | uncertain significance |
| rs1266534046 | 8:130,789,829 | G/C | — | uncertain significance |
Gene information from NCBI Gene. Variant classifications from ClinVar.