rs6470764

This variant is located in the GSDMC gene.

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GWAS Catalog Trait Associations (4)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

body height

Verma A et al. “Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.” Science (new York, N.y.) 385(6706):eadj1182 (2024)
Allele C
OR 0.12
p 8.0e-273
N 424,306
Major Consortium StudyLarge GWAS
European
Lango Allen H et al. “Hundreds of variants clustered in genomic loci and biological pathways affect human height.” Nature 467(7317):832-8 (2010)
Allele C
OR —
β 0.050
p 2.0e-28
N 133,653
Large GWAS
European
Chiou JS et al. “Your height affects your health: genetic determinants and health-related outcomes in Taiwan.” Bmc Medicine 20(1):250 (2022)
Allele C
OR 0.04
p 1.0e-13
N 67,452
Large GWAS
East Asian

osteoarthritis

Hatzikotoulas K et al. “Translational genomics of osteoarthritis in 1,962,069 individuals.” Nature 641(8065):1217-1224 (2025)
Allele T
OR 0.97
p 9.0e-11
N 1,962,069
Large GWAS
multi-ancestry

BMI-adjusted hip circumference

Shungin D et al. “New genetic loci link adipose and insulin biology to body fat distribution.” Nature 518(7538):187-196 (2015)
Allele T
OR 0.04
p 2.0e-9
N 143,480
Large GWAS
multi-ancestry

vertebral column disorder

Verma A et al. “Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.” Science (new York, N.y.) 385(6706):eadj1182 (2024)
Allele C
OR 0.05
p 1.0e-12
N 408,566
Major Consortium StudyLarge GWAS
European

About GSDMC

Enables wide pore channel activity. Involved in pyroptotic inflammatory response. Located in cytoplasm. Is active in plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

View all GSDMC variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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