TNC

tenascin C

Summary

This gene encodes an extracellular matrix protein with a spatially and temporally restricted tissue distribution. This protein is homohexameric with disulfide-linked subunits, and contains multiple EGF-like and fibronectin type-III domains. It is implicated in guidance of migrating neurons as well as axons during development, synaptic plasticity, and neuronal regeneration. [provided by RefSeq, Jul 2011]

Known Variants399 total

rsid	Position (GRCh37)	Alleles	Class	ClinVar
rs10982496	9:117,782,482	C/G	downstream gene variant	—
rs868055775	9:117,783,441	C/A	—	uncertain significance
rs565506426	9:117,783,449	C/T	—	likely benign
rs143636742	9:117,783,450	G/A	—	uncertain significance
rs1829040148	9:117,783,515	T/C	—	uncertain significance
rs149752009	9:117,783,543	C/T	—	likely benign
rs200330029	9:117,786,253	T/C	—	uncertain significance
rs75198247	9:117,786,265	T/C	—	benign
rs10982498	9:117,786,508	G/A	—	benign
rs142272539	9:117,788,871	G/A	—	likely benign
rs866729657	9:117,788,909	G/T	—	uncertain significance
rs371541652	9:117,788,914	C/T	—	likely benign
rs754190580	9:117,788,927	G/A	—	uncertain significance
rs140573419	9:117,788,933	C/T	—	uncertain significance
rs1829509005	9:117,788,957	T/C	—	uncertain significance
rs1007186322	9:117,788,965	T/A	—	uncertain significance
rs780884731	9:117,788,967	G/T	—	uncertain significance
rs75904854	9:117,789,002	G/A	—	benign
rs183619566	9:117,791,384	T/C	—	likely benign
rs78708802	9:117,791,406	T/A	—	likely benign
rs142249284	9:117,791,512	G/C	—	likely benign
rs12346540	9:117,791,617	T/C	—	benign
rs565954577	9:117,791,660	G/A	—	likely benign
rs79563958	9:117,791,664	C/T	—	benign
rs58547879	9:117,791,709	G/A	—	benign
rs1829786933	9:117,791,729	G/T	—	uncertain significance
rs377288198	9:117,791,730	G/A	—	likely benign
rs367685240	9:117,791,739	T/C	—	likely benign
rs13286217	9:117,792,274	G/C	—	benign
rs13286441	9:117,792,426	T/G	—	benign
rs60312520	9:117,792,443	C/T	—	likely benign
rs13321	9:117,792,583	C/G	missense variant	benign
rs61736828	9:117,792,599	C/T	—	likely benign
rs2131648755	9:117,792,618	C/G	—	uncertain significance
rs373428721	9:117,792,627	G/A	—	conflicting classifications of pathogenicity
rs2274753	9:117,792,876	A/T	—	benign
rs79003972	9:117,793,657	T/C	—	benign
rs1321724421	9:117,793,837	G/A	—	uncertain significance
rs199684970	9:117,793,846	G/A	—	uncertain significance
rs532308103	9:117,793,906	G/A	—	uncertain significance
rs2539015852	9:117,793,907	T/C	—	uncertain significance
rs113316909	9:117,793,942	G/A	—	likely benign
rs11788513	9:117,794,154	G/A	—	benign
rs3789875	9:117,795,288	C/G	—	—
rs1330361	9:117,797,394	G/A	—	benign
rs747230674	9:117,797,512	C/A	—	uncertain significance
rs10118726	9:117,797,525	G/T	—	benign
rs1180536647	9:117,797,527	T/C	—	uncertain significance
rs530735519	9:117,797,538	C/T	—	conflicting classifications of pathogenicity
rs148674204	9:117,797,539	G/A	—	uncertain significance
rs751983534	9:117,797,540	G/A	—	likely benign
rs550427608	9:117,797,544	G/T	—	uncertain significance
rs1046190165	9:117,797,547	C/T	—	uncertain significance
rs749516851	9:117,797,548	G/A	—	uncertain significance
rs150811111	9:117,797,570	C/T	—	likely benign
rs2539120543	9:117,797,578	C/T	—	uncertain significance
rs12347433	9:117,797,597	T/C	synonymous variant	benign
rs566154461	9:117,797,598	C/T	—	uncertain significance
rs368535573	9:117,797,622	G/A	—	likely benign
rs2539156032	9:117,798,388	T/G	—	uncertain significance
rs139636928	9:117,798,418	C/G	—	likely benign
rs144325005	9:117,798,420	T/C	—	likely benign
rs1394493737	9:117,798,422	T/C	—	uncertain significance
rs755156996	9:117,798,502	G/A	—	likely benign
rs200602864	9:117,798,505	C/T	—	uncertain significance
rs147209833	9:117,798,625	G/A	—	likely benign
rs151194379	9:117,798,811	T/A	—	likely benign
rs28393206	9:117,798,832	G/C	—	benign
rs10982503	9:117,798,837	C/T	—	benign
rs2274751	9:117,800,417	T/A	—	benign
rs12553939	9:117,800,472	C/T	—	likely benign
rs774393174	9:117,800,546	C/T	—	conflicting classifications of pathogenicity
rs1830482789	9:117,800,573	C/A	—	uncertain significance
rs75621471	9:117,800,694	T/C	—	benign
rs10817703	9:117,802,985	G/T	—	benign
rs431905513	9:117,803,226	T/A	missense variant	pathogenic
rs142378274	9:117,803,261	C/T	—	uncertain significance
rs2539344059	9:117,803,267	A/G	—	uncertain significance
rs1422851287	9:117,803,268	T/C	—	uncertain significance
rs2274750	9:117,803,271	C/T	—	benign
rs137933052	9:117,803,295	C/T	missense variant	pathogenic
rs1830693385	9:117,803,307	G/A	—	uncertain significance
rs375283743	9:117,803,313	C/A	—	uncertain significance
rs113892305	9:117,803,337	C/T	—	uncertain significance
rs16932096	9:117,803,380	G/C	—	benign
rs12352614	9:117,803,580	A/G	—	benign
rs62578746	9:117,803,583	A/C	—	benign
rs12343556	9:117,803,588	C/G	—	benign
rs78768361	9:117,803,590	G/C	—	benign
rs58156981	9:117,803,593	G/A	—	benign
rs12352616	9:117,803,594	A/G	—	benign
rs189412566	9:117,803,611	C/T	—	likely benign
rs10759752	9:117,803,720	G/A	intron variant	—
rs12343737	9:117,804,027	C/T	intron variant	—
rs77775842	9:117,804,400	A/C	—	benign
rs1246681473	9:117,804,499	T/A	—	pathogenic
rs773026384	9:117,804,507	T/A	—	uncertain significance
rs762614232	9:117,804,515	T/C	—	uncertain significance
rs62638694	9:117,804,523	C/T	—	likely benign
rs149299073	9:117,804,524	C/T	—	likely benign

Showing 100 of 399 variants. Use the SNP search for the full list.

Gene information from NCBI Gene. Variant classifications from ClinVar.