rs1800437

This is a protein-altering variant in the GIPR gene.

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GWAS Catalog Trait Associations (20)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

body mass index

Huang J et al. “Genomics and phenomics of body mass index reveals a complex disease network.” Nature Communications 13(1):7973 (2022)
Allele G
OR 0.03
p 5.0e-90
N 1,122,049
Large GWAS
European
Verma A et al. “Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.” Science (new York, N.y.) 385(6706):eadj1182 (2024)
Allele G
OR 0.06
p 7.0e-53
N 607,391
Major Consortium StudyLarge GWAS
multi-ancestry
Turcot V et al. “Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity.” Nature Genetics 50(1):26-41 (2018)
Allele G
OR 0.03
p 6.0e-45
N 526,508
Large GWAS
multi-ancestry
Pulit SL et al. “Meta-analysis of genome-wide association studies for body fat distribution in 694 649 individuals of European ancestry.” Human Molecular Genetics 28(1):166-174 (2019)
Allele G
OR 0.03
p 3.0e-59
N 374,756
Meta-analysisLarge GWAS
European
Graff M et al. “Genome-wide physical activity interactions in adiposity - A meta-analysis of 200,452 adults.” Plos Genetics 13(4):e1006528 (2017)
Allele G
OR 0.03
p 2.0e-9
N 123,097
Meta-analysisLarge GWAS
multi-ancestry

body weight

Verma A et al. “Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.” Science (new York, N.y.) 385(6706):eadj1182 (2024)
Allele G
OR 0.06
p 3.0e-50
N 609,198
Major Consortium StudyLarge GWAS
multi-ancestry

blood urea nitrogen amount

Verma A et al. “Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.” Science (new York, N.y.) 385(6706):eadj1182 (2024)
Allele G
OR 0.04
p 2.0e-36
N 599,920
Major Consortium StudyLarge GWAS
multi-ancestry

obesity

Verma A et al. “Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.” Science (new York, N.y.) 385(6706):eadj1182 (2024)
Allele G
OR 0.06
p 5.0e-34
N 413,854
Major Consortium StudyLarge GWAS
European
Berndt SI et al. “Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture.” Nature Genetics 45(5):501-12 (2013)
Allele G
OR 1.10
p 3.0e-14
N 204,498
Meta-analysisLarge GWAS
European

overnutrition, obesity

Verma A et al. “Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.” Science (new York, N.y.) 385(6706):eadj1182 (2024)
Allele G
OR 0.05
p 2.0e-29
N 406,236
Major Consortium StudyLarge GWAS
European

morbid obesity

Verma A et al. “Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.” Science (new York, N.y.) 385(6706):eadj1182 (2024)
Allele G
OR 0.09
p 7.0e-27
N 431,717
Major Consortium StudyLarge GWAS
European

glucose tolerance test

Chen J et al. “The trans-ancestral genomic architecture of glycemic traits.” Nature Genetics 53(6):840-860 (2021)
Allele C
OR 0.10
p 5.0e-26
N 63,396
Large GWAS
European
Willems SM et al. “Large-scale exome array summary statistics resources for glycemic traits to aid effector gene prioritization.” Wellcome Open Research 8:483 (2023)
Allele C
OR 0.10
p 3.0e-23
N 57,878
Large GWAS
multi-ancestry

waist-hip ratio

Pulit SL et al. “Meta-analysis of genome-wide association studies for body fat distribution in 694 649 individuals of European ancestry.” Human Molecular Genetics 28(1):166-174 (2019)
Allele C
OR 0.02
p 6.0e-22
N 697,734
Meta-analysisLarge GWAS
European

diet measurement

Cole JB et al. “Comprehensive genomic analysis of dietary habits in UK Biobank identifies hundreds of genetic associations.” Nature Communications 11(1):1467 (2020)
Allele G
OR 0.02
p 6.0e-17
N 449,210
Major Consortium StudyLarge GWAS
European

bladder calculus

Verma A et al. “Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.” Science (new York, N.y.) 385(6706):eadj1182 (2024)
Allele G
OR 0.07
p 3.0e-15
N 616,206
Major Consortium StudyLarge GWAS
multi-ancestry
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Research that mentions this SNP (2)

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Candidate gene association study of type 2 diabetes in a nested case‐control study of the EPIC‐Potsdam cohort – Role of fat assimilation
AssociationN=576Eva Fisher et al.(2007)· Molecular Nutrition &amp; Food Research

Candidate gene association study screening 15 genes involved in fat assimilation for type 2 diabetes susceptibility. In 192 cases and 384 controls from EPIC-Potsdam, six SNPs showed significant associations: FABP6 Thr79Met (rs1130435, OR=0.45, 95% CI 0.22-0.92) showed the strongest protective effect; DBI rs2084202 and rs8192506 (Met71Val), PTGES2 rs13283456 (Arg298His, OR=0.64), SLC27A5 promoter variant (OR=0.54), and novel CLPS Ala109Cys variant (OR=5.83) also associated with diabetes risk. Results provide preliminary evidence for fat assimilation genes in type 2 diabetes susceptibility but require further verification.

Traits studied:Type 2 diabetes
PubMedDOIMetascience Observatory
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Association analyses of GIP and GIPR polymorphisms with traits of the metabolic syndrome
AssociationN=17,309Inke Nitz et al.(2007)· Molecular Nutrition &amp; Food Research

This association study examined three GIPR (gastric inhibitory polypeptide receptor) SNPs (rs8111428, rs2302382, rs1800437) across 761 German obesity families and validation samples. The A-allele of rs2302382 showed significant association with obesity (OR=1.54, 95% CI 1.09-2.19, p=0.014 in case-control analysis) and was over-transmitted in families (p=0.0089), while rs8111428 G-allele also showed transmission disequilibrium (p=0.0016). However, results were conflicting in population-based studies: KORA showed a trend toward increased BMI with the A-allele (p=0.136) while SHIP showed an opposite association (p=0.031), suggesting geographic or phenotypic stratification effects.

Traits studied:Body Mass Index (BMI)Obesity
PubMedDOIMetascience Observatory

About GIPR

This gene encodes a G-protein coupled receptor for gastric inhibitory polypeptide (GIP), which was originally identified as an activity in gut extracts that inhibited gastric acid secretion and gastrin release, but subsequently was demonstrated to stimulate insulin release in the presence of elevated glucose. Mice lacking this gene exhibit higher blood glucose levels with impaired initial insulin response after oral glucose load. Defect in this gene thus may contribute to the pathogenesis of diabetes. [provided by RefSeq, Oct 2011]

View all GIPR variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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