GIPR

gastric inhibitory polypeptide receptor

Summary

This gene encodes a G-protein coupled receptor for gastric inhibitory polypeptide (GIP), which was originally identified as an activity in gut extracts that inhibited gastric acid secretion and gastrin release, but subsequently was demonstrated to stimulate insulin release in the presence of elevated glucose. Mice lacking this gene exhibit higher blood glucose levels with impaired initial insulin response after oral glucose load. Defect in this gene thus may contribute to the pathogenesis of diabetes. [provided by RefSeq, Oct 2011]

Known Variants31 total

rsidPosition (GRCh37)AllelesClassClinVar
rs1167166419:46,172,278G/Aregulatory region variant
rs37424718719:46,172,800C/Guncertain significance
rs197542751519:46,172,812C/Guncertain significance
rs132636887219:46,172,825G/Auncertain significance
rs75044327919:46,172,827G/Auncertain significance
rs128357929519:46,172,846C/Guncertain significance
rs76925099019:46,173,912C/Auncertain significance
rs103153280319:46,173,921A/Guncertain significance
rs77345601619:46,173,927A/Cuncertain significance
rs1330640119:46,174,378C/Aregulatory region variant
rs14349017319:46,174,567A/Tuncertain significance
rs3556003819:46,175,046A/G
rs251359102219:46,176,159C/Guncertain significance
rs76946173919:46,177,334C/Auncertain significance
rs76441624419:46,177,366T/Cuncertain significance
rs223869119:46,179,043G/Adownstream gene variant
rs75627763419:46,180,355T/Auncertain significance
rs20198098519:46,180,969T/Cuncertain significance
rs14343088019:46,180,976A/Gmissense variant
rs77706558519:46,181,011C/Tuncertain significance
rs37304004119:46,181,024T/Guncertain significance
rs37647188919:46,181,026A/Guncertain significance
rs180043719:46,181,392G/Cmissense variant
rs160031153119:46,181,399T/Cuncertain significance
rs77782680519:46,181,440C/Auncertain significance
rs1042392819:46,182,304T/Adownstream gene variant
rs76611996119:46,185,002C/Auncertain significance
rs146688723919:46,185,023C/Tuncertain significance
rs196725290519:46,185,035A/Guncertain significance
rs20095814719:46,185,036G/Tuncertain significance
rs19987184719:46,185,131T/Auncertain significance

Gene information from NCBI Gene. Variant classifications from ClinVar.