rs11671664

This is a regulatory region variant variant in the GIPR gene.

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GWAS Catalog Trait Associations (2)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

body mass index

Akiyama M et al. “Genome-wide association study identifies 112 new loci for body mass index in the Japanese population.” Nature Genetics 49(10):1458-1467 (2017)
Allele A
OR 0.04
p 3.0e-42
N 158,284
Large GWAS
multi-ancestry
Wen W et al. “Meta-analysis of genome-wide association studies in East Asian-ancestry populations identifies four new loci for body mass index.” Human Molecular Genetics 23(20):5492-504 (2014)
Allele A
OR 0.04
p 3.0e-12
N 86,739
Meta-analysisLarge GWAS
multi-ancestry
Wen W et al. “Meta-analysis identifies common variants associated with body mass index in east Asians.” Nature Genetics 44(3):307-11 (2012)
Allele A
OR 4.22
p 6.0e-14
N 27,715
Meta-analysisLarge GWAS
multi-ancestry
Okada Y et al. “Common variants at CDKAL1 and KLF9 are associated with body mass index in east Asian populations.” Nature Genetics 44(3):302-6 (2012)
Allele A
OR 0.05
p 7.0e-14
N 26,620
Large GWAS
East Asian

type 2 diabetes mellitus

Zhao W et al. “Identification of new susceptibility loci for type 2 diabetes and shared etiological pathways with coronary heart disease.” Nature Genetics 49(10):1450-1457 (2017)
Allele A
OR 0.08
p 3.0e-12
N 183,651
Large GWAS
multi-ancestry

About GIPR

This gene encodes a G-protein coupled receptor for gastric inhibitory polypeptide (GIP), which was originally identified as an activity in gut extracts that inhibited gastric acid secretion and gastrin release, but subsequently was demonstrated to stimulate insulin release in the presence of elevated glucose. Mice lacking this gene exhibit higher blood glucose levels with impaired initial insulin response after oral glucose load. Defect in this gene thus may contribute to the pathogenesis of diabetes. [provided by RefSeq, Oct 2011]

View all GIPR variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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