ADCY3
adenylate cyclase 3
Summary
This gene encodes adenylyl cyclase 3 which is a membrane-associated enzyme and catalyzes the formation of the secondary messenger cyclic adenosine monophosphate (cAMP). This protein appears to be widely expressed in various human tissues and may be involved in a number of physiological and pathophysiological metabolic processes. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2016]
Known Variants259 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs201348363 | 2:25,042,792 | C/T | — | likely benign |
| rs778587134 | 2:25,042,832 | G/A | — | uncertain significance |
| rs757959559 | 2:25,042,836 | C/T | — | uncertain significance |
| rs142510036 | 2:25,042,846 | A/G | — | benign |
| rs2466516975 | 2:25,042,884 | A/C | — | uncertain significance |
| rs746113754 | 2:25,042,929 | G/T | — | likely benign |
| rs775633915 | 2:25,042,940 | C/T | — | uncertain significance |
| rs149824724 | 2:25,042,947 | C/T | — | uncertain significance |
| rs541665903 | 2:25,042,992 | G/A | — | likely benign |
| rs776111289 | 2:25,043,588 | C/A | — | uncertain significance |
| rs146553503 | 2:25,043,610 | C/T | — | uncertain significance |
| rs761523411 | 2:25,043,614 | C/T | — | likely benign |
| rs537915767 | 2:25,043,615 | G/A | — | uncertain significance |
| rs1157750996 | 2:25,043,623 | C/T | — | uncertain significance |
| rs2466563346 | 2:25,043,629 | G/A | — | likely benign |
| rs1427403684 | 2:25,043,641 | G/A | — | likely benign |
| rs1402883983 | 2:25,043,662 | G/A | — | likely benign |
| rs556248650 | 2:25,043,704 | G/A | — | likely benign |
| rs2466568158 | 2:25,043,725 | A/C | — | likely benign |
| rs138929956 | 2:25,044,374 | G/A | — | benign |
| rs188738597 | 2:25,044,375 | G/C | — | benign |
| rs752934161 | 2:25,044,388 | A/G | — | uncertain significance |
| rs750100320 | 2:25,044,391 | C/T | — | uncertain significance |
| rs1483615736 | 2:25,044,399 | G/A | — | likely benign |
| rs72792178 | 2:25,044,417 | G/A | — | likely benign |
| rs779611664 | 2:25,044,435 | C/T | — | likely benign |
| rs747746171 | 2:25,044,461 | C/T | — | uncertain significance |
| rs77454507 | 2:25,044,462 | G/A | — | likely benign |
| rs751871836 | 2:25,044,490 | T/G | — | uncertain significance |
| rs755247497 | 2:25,044,498 | G/A | — | likely benign |
| rs147179390 | 2:25,045,383 | G/T | — | likely benign |
| rs777264230 | 2:25,045,401 | A/G | — | likely benign |
| rs1040135012 | 2:25,045,405 | G/C | — | uncertain significance |
| rs139344556 | 2:25,045,416 | G/A | — | likely benign |
| rs146622426 | 2:25,045,434 | C/T | — | likely benign |
| rs770197713 | 2:25,045,467 | G/T | — | likely benign |
| rs76847777 | 2:25,045,517 | G/T | — | likely benign |
| rs1668049134 | 2:25,046,077 | C/G | — | likely pathogenic |
| rs1127568 | 2:25,046,090 | T/C | synonymous variant | benign |
| rs375101795 | 2:25,046,159 | G/A | — | likely benign |
| rs1433512698 | 2:25,046,205 | T/C | — | uncertain significance |
| rs143693626 | 2:25,046,207 | C/T | — | likely benign |
| rs776200284 | 2:25,046,208 | G/A | — | uncertain significance |
| rs1668298380 | 2:25,047,260 | T/G | — | uncertain significance |
| rs769120427 | 2:25,047,318 | C/T | — | uncertain significance |
| rs199524620 | 2:25,047,327 | G/A | — | uncertain significance |
| rs1336234399 | 2:25,047,331 | C/T | — | uncertain significance |
| rs780327182 | 2:25,047,340 | G/A | — | likely benign |
| rs766627903 | 2:25,047,385 | T/C | — | likely benign |
| rs1553333167 | 2:25,047,406 | C/T | — | risk factor |
| rs7604576 | 2:25,047,408 | A/G | splice region variant | benign |
| rs371984222 | 2:25,048,904 | C/T | — | likely benign |
| rs147136309 | 2:25,048,914 | G/A | — | uncertain significance |
| rs768438599 | 2:25,048,917 | G/T | — | likely benign |
| rs367811817 | 2:25,048,924 | A/T | — | uncertain significance |
| rs1287549026 | 2:25,048,940 | G/C | — | uncertain significance |
| rs572878903 | 2:25,048,951 | A/C | — | uncertain significance |
| rs148560577 | 2:25,048,962 | C/T | — | benign |
| rs146165057 | 2:25,048,965 | C/T | — | likely benign |
| rs1053324415 | 2:25,048,974 | C/T | — | likely benign |
| rs748070365 | 2:25,049,008 | G/A | — | uncertain significance |
| rs147113861 | 2:25,049,010 | G/A | — | benign |
| rs72792187 | 2:25,049,618 | A/G | — | — |
| rs751226954 | 2:25,050,403 | C/T | — | likely benign |
| rs201882277 | 2:25,050,404 | G/A | — | likely benign |
| rs116538472 | 2:25,050,407 | G/A | — | benign |
| rs1037666380 | 2:25,050,426 | A/G | — | likely benign |
| rs1159093126 | 2:25,050,470 | T/C | — | uncertain significance |
| rs1331776405 | 2:25,050,478 | C/T | — | risk factor |
| rs565303281 | 2:25,050,758 | C/T | — | likely benign |
| rs2466828704 | 2:25,050,760 | C/T | — | likely benign |
| rs139420185 | 2:25,050,773 | G/A | — | likely benign |
| rs1172748897 | 2:25,050,774 | T/C | — | uncertain significance |
| rs1275702168 | 2:25,050,779 | C/T | — | likely benign |
| rs560339786 | 2:25,050,780 | C/G | — | uncertain significance |
| rs185180064 | 2:25,050,786 | C/T | — | uncertain significance |
| rs373035912 | 2:25,050,787 | G/A | — | uncertain significance |
| rs1201956210 | 2:25,050,788 | C/T | — | likely benign |
| rs377506465 | 2:25,050,797 | G/A | — | likely benign |
| rs774738640 | 2:25,050,806 | A/G | — | likely benign |
| rs369803323 | 2:25,050,811 | C/T | — | conflicting classifications of pathogenicity |
| rs758474445 | 2:25,050,844 | C/T | — | uncertain significance |
| rs779982153 | 2:25,050,845 | G/A | — | likely benign |
| rs779412964 | 2:25,050,856 | C/T | — | uncertain significance |
| rs750011135 | 2:25,050,914 | G/A | — | likely benign |
| rs146981649 | 2:25,050,954 | T/C | — | uncertain significance |
| rs7566416 | 2:25,050,977 | T/C | — | benign |
| rs766366885 | 2:25,050,989 | C/T | — | likely benign |
| rs917820514 | 2:25,050,990 | G/A | — | uncertain significance |
| rs1558410394 | 2:25,051,002 | G/T | — | uncertain significance |
| rs200197892 | 2:25,051,007 | C/T | — | likely benign |
| rs759311730 | 2:25,051,008 | G/A | — | uncertain significance |
| rs75629912 | 2:25,051,044 | C/T | — | likely benign |
| rs749288972 | 2:25,053,586 | C/T | — | uncertain significance |
| rs770768026 | 2:25,053,632 | G/A | — | likely benign |
| rs2466909326 | 2:25,053,642 | C/T | — | uncertain significance |
| rs2466910079 | 2:25,053,658 | T/C | — | uncertain significance |
| rs763137888 | 2:25,053,671 | G/C | — | likely benign |
| rs201250613 | 2:25,053,679 | G/T | — | uncertain significance |
| rs80261757 | 2:25,053,704 | A/G | — | likely benign |
Showing 100 of 259 variants. Use the SNP search for the full list.
Gene information from NCBI Gene. Variant classifications from ClinVar.