rs17381664
This is a intron variant variant in the ZZZ3 gene.
▶GWAS Catalog Trait Associations (4)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
GWAS Catalog Trait Associations (4)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
body mass index
Hoffmann TJ et al. “A Large Multiethnic Genome-Wide Association Study of Adult Body Mass Index Identifies Novel Loci.” Genetics 210(2):499-515 (2018)
Allele T
OR —
β 0.021
p 3.0e-15
N 334,487
Large GWAS
multi-ancestry
Winkler TW et al. “The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study.” Plos Genetics 11(10):e1005378 (2015)
Allele T
OR —
β 0.022
p 1.0e-14
N 309,889
Large GWAS
European
obesity
Berndt SI et al. “Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture.” Nature Genetics 45(5):501-12 (2013)
Allele C
OR 1.09
p 3.0e-8
N 204,498
Meta-analysisLarge GWAS
European
diastolic blood pressure
Surendran P et al. “Discovery of rare variants associated with blood pressure regulation through meta-analysis of 1.3 million individuals.” Nature Genetics 52(12):1314-1332 (2020)
Allele T
OR 0.09
p 1.0e-10
N 1,164,961
Meta-analysisLarge GWAS
European
physical activity measurement, body mass index
Graff M et al. “Genome-wide physical activity interactions in adiposity - A meta-analysis of 200,452 adults.” Plos Genetics 13(4):e1006528 (2017)
Allele C
OR 0.02
p 1.0e-8
N 161,368
Meta-analysisLarge GWAS
multi-ancestry
About ZZZ3
Enables histone reader activity; lysine-acetylated histone binding activity; and methylated histone binding activity. Involved in several processes, including chromatin organization; regulation of cell division; and regulation of transcription by RNA polymerase II. Located in nucleolus and nucleoplasm. Part of ATAC complex. [provided by Alliance of Genome Resources, Apr 2025]
View all ZZZ3 variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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