rs4923464

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GWAS Catalog Trait Associations (9)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

smoking initiation

Saunders GRB et al. “Genetic diversity fuels gene discovery for tobacco and alcohol use.” Nature 612(7941):720-724 (2022)
Allele T
OR 0.02
p 2.0e-77
N 3,382,012
Large GWAS
European, East Asian, Hispanic or Latin American, African unspecified

body mass index

Verma A et al. “Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.” Science (new York, N.y.) 385(6706):eadj1182 (2024)
Allele C
OR 0.06
p 2.0e-49
N 607,391
Major Consortium StudyLarge GWAS
multi-ancestry

body weight

Verma A et al. “Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.” Science (new York, N.y.) 385(6706):eadj1182 (2024)
Allele C
OR 0.06
p 4.0e-39
N 609,198
Major Consortium StudyLarge GWAS
multi-ancestry

obesity

Verma A et al. “Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.” Science (new York, N.y.) 385(6706):eadj1182 (2024)
Allele C
OR 0.05
p 2.0e-18
N 585,585
Major Consortium StudyLarge GWAS
multi-ancestry

overnutrition, obesity

Verma A et al. “Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.” Science (new York, N.y.) 385(6706):eadj1182 (2024)
Allele C
OR 0.05
p 3.0e-16
N 575,115
Major Consortium StudyLarge GWAS
multi-ancestry

blood sodium bicarbonate amount

Verma A et al. “Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.” Science (new York, N.y.) 385(6706):eadj1182 (2024)
Allele C
OR 0.03
p 5.0e-14
N 585,125
Major Consortium StudyLarge GWAS
multi-ancestry

morbid obesity

Verma A et al. “Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.” Science (new York, N.y.) 385(6706):eadj1182 (2024)
Allele C
OR 0.07
p 1.0e-12
N 611,383
Major Consortium StudyLarge GWAS
multi-ancestry

type 2 diabetes mellitus

Mahajan A et al. “Multi-ancestry genetic study of type 2 diabetes highlights the power of diverse populations for discovery and translation.” Nature Genetics 54(5):560-572 (2022)
Allele C
OR 1.03
p 3.0e-8
N 492,192
Large GWAS
multi-ancestry
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Research that mentions this SNP (1)

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Significant association of BDNF haplotypes in European‐American male smokers but not in European‐American female or African‐American smokers
FunctionalN=300Joke Beuten et al.(2005)· American Journal of Medical Genetics Part B: Neuropsychiatric Genetics

This study analyzed genotype-expression interactions for BDNF across five human brain regions using GTEx data from 300 subjects (985 tissue samples). At FDR < 0.1, 61 SNPs in cerebellum, 55 in cortex, 48 in nucleus accumbens, 47 in caudate, and 58 in cerebellar hemisphere were associated with BDNF expression. Thirty SNPs in two haplotype blocks were shared across all five regions, including rs6265 (Val66Met), rs16917204, rs11030104, and rs6484320, which have been previously associated with psychiatric disorders including depression, bipolar disorder, schizophrenia, OCD, epilepsy, and addiction.

Traits studied:Alzheimer's diseaseBDNF expressionBipolar disorderDepressionEating disordersEpilepsyMethamphetamine abuseNicotine addictionObsessive-compulsive disorderPanic disorderPost-traumatic stress disorderSchizophreniaSubstance use disorders
PubMedDOIMetascience Observatory

This variant is in our database but has no known associations or PRS memberships yet.

Gene information from NCBI Gene. Variant classifications from ClinVar.

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