rs71559024
This is a upstream gene variant variant in the ZNF391 gene.
▶GWAS Catalog Trait Associations (2)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
GWAS Catalog Trait Associations (2)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
substance-related disorder
Lai D et al. “Genome-wide meta-analyses of cross substance use disorders in diverse populations.” Molecular Psychiatry 31(3):1619-1633 (2026)
Allele A
OR 8.41
p 4.0e-17
N 1,458,999
Large GWAS
European
Hernia
Ahmed WU et al. “Shared genetic architecture of hernias: A genome-wide association study with multivariable meta-analysis of multiple hernia phenotypes.” Plos One 17(12):e0272261 (2022)
Allele G
OR —
p 4.0e-14
N 344,508
Meta-analysisLarge GWAS
European
About ZNF391
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]
View all ZNF391 variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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