ADGRL3
adhesion G protein-coupled receptor L3
Summary
This gene encodes a member of the latrophilin subfamily of G-protein coupled receptors (GPCR). Latrophilins may function in both cell adhesion and signal transduction. In experiments with non-human species, endogenous proteolytic cleavage within a cysteine-rich GPS (G-protein-coupled-receptor proteolysis site) domain resulted in two subunits (a large extracellular N-terminal cell adhesion subunit and a subunit with substantial similarity to the secretin/calcitonin family of GPCRs) being non-covalently bound at the cell membrane. [provided by RefSeq, Jul 2008]
Known Variants64 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs1394950 | 4:62,083,448 | T/A | — | — |
| rs1505676 | 4:62,127,291 | G/C | intron variant | — |
| rs13136685 | 4:62,244,910 | G/C | — | — |
| rs28540500 | 4:62,409,801 | G/C | regulatory region variant | — |
| rs4860418 | 4:62,421,204 | C/T | intron variant | — |
| rs573890687 | 4:62,427,056 | T/C | — | — |
| rs6856328 | 4:62,437,318 | C/G | intron variant | — |
| rs764433793 | 4:62,452,981 | G/A | — | uncertain significance |
| rs745351934 | 4:62,453,043 | A/G | — | uncertain significance |
| rs2172802 | 4:62,453,209 | A/G | intron variant | — |
| rs541482709 | 4:62,473,251 | G/A | — | — |
| rs766951668 | 4:62,542,600 | C/T | — | uncertain significance |
| rs7678046 | 4:62,596,693 | C/A | — | — |
| rs191915391 | 4:62,598,548 | G/A | — | likely benign |
| rs961631696 | 4:62,598,601 | C/G | — | uncertain significance |
| rs2548675184 | 4:62,598,651 | A/G | — | uncertain significance |
| rs370533278 | 4:62,598,666 | A/G | — | uncertain significance |
| rs148616574 | 4:62,598,951 | C/G | — | uncertain significance |
| rs553955973 | 4:62,599,124 | G/T | — | uncertain significance |
| rs1901223 | 4:62,660,731 | G/A | intron variant | — |
| rs2545980275 | 4:62,679,598 | T/C | — | likely benign |
| rs6551665 | 4:62,739,541 | G/A | intron variant | — |
| rs1947274 | 4:62,744,240 | C/T | — | — |
| rs1947275 | 4:62,744,545 | T/C | intron variant | — |
| rs768031330 | 4:62,758,407 | G/A | — | uncertain significance |
| rs373736658 | 4:62,758,430 | C/T | — | uncertain significance |
| rs775138320 | 4:62,758,586 | A/G | — | uncertain significance |
| rs778927229 | 4:62,758,632 | G/A | — | uncertain significance |
| rs769339594 | 4:62,758,673 | A/G | — | uncertain significance |
| rs369695278 | 4:62,758,674 | T/C | — | uncertain significance |
| rs746371361 | 4:62,761,541 | A/G | — | uncertain significance |
| rs2345039 | 4:62,765,030 | G/C | intron variant | — |
| rs6813183 | 4:62,769,131 | G/T | — | — |
| rs192210727 | 4:62,775,333 | G/T | missense variant | — |
| rs1355368 | 4:62,779,822 | A/T | — | — |
| rs734644 | 4:62,800,728 | T/A | missense variant | — |
| rs759192439 | 4:62,812,663 | C/A | — | uncertain significance |
| rs376555701 | 4:62,812,713 | C/T | — | uncertain significance |
| rs767309934 | 4:62,812,757 | G/A | — | uncertain significance |
| rs372785017 | 4:62,813,870 | G/A | — | uncertain significance |
| rs754347191 | 4:62,813,906 | G/A | — | uncertain significance |
| rs377117985 | 4:62,813,929 | C/T | — | uncertain significance |
| rs777317990 | 4:62,813,935 | A/G | — | uncertain significance |
| rs1229273694 | 4:62,845,398 | A/G | — | uncertain significance |
| rs552348244 | 4:62,845,432 | T/G | — | uncertain significance |
| rs370040630 | 4:62,845,477 | G/A | — | uncertain significance |
| rs28634184 | 4:62,873,419 | C/T | intron variant | — |
| rs1471553825 | 4:62,894,575 | A/G | — | uncertain significance |
| rs1361360622 | 4:62,897,296 | A/G | — | uncertain significance |
| rs2548611289 | 4:62,903,563 | A/C | — | uncertain significance |
| rs1222861886 | 4:62,910,180 | C/T | — | uncertain significance |
| rs9998041 | 4:62,914,954 | G/T | intron variant | — |
| rs1745098999 | 4:62,935,853 | A/T | — | uncertain significance |
| rs769999033 | 4:62,935,952 | C/G | — | uncertain significance |
| rs562476045 | 4:62,936,093 | C/T | — | uncertain significance |
| rs2476346565 | 4:62,936,096 | G/T | — | uncertain significance |
| rs2476352834 | 4:62,936,220 | A/C | — | uncertain significance |
| rs748448343 | 4:62,936,372 | G/A | — | uncertain significance |
| rs771497064 | 4:62,936,384 | G/A | — | uncertain significance |
| rs758755904 | 4:62,936,450 | G/A | — | uncertain significance |
| rs1293140886 | 4:62,936,462 | A/G | — | uncertain significance |
| rs1163385735 | 4:62,936,481 | G/A | — | uncertain significance |
| rs2476368363 | 4:62,936,489 | A/C | — | uncertain significance |
| rs1429529696 | 4:62,936,544 | G/T | — | uncertain significance |
Gene information from NCBI Gene. Variant classifications from ClinVar.