ADGRL3

adhesion G protein-coupled receptor L3

Summary

This gene encodes a member of the latrophilin subfamily of G-protein coupled receptors (GPCR). Latrophilins may function in both cell adhesion and signal transduction. In experiments with non-human species, endogenous proteolytic cleavage within a cysteine-rich GPS (G-protein-coupled-receptor proteolysis site) domain resulted in two subunits (a large extracellular N-terminal cell adhesion subunit and a subunit with substantial similarity to the secretin/calcitonin family of GPCRs) being non-covalently bound at the cell membrane. [provided by RefSeq, Jul 2008]

Known Variants64 total

rsidPosition (GRCh37)AllelesClassClinVar
rs13949504:62,083,448T/A
rs15056764:62,127,291G/Cintron variant
rs131366854:62,244,910G/C
rs285405004:62,409,801G/Cregulatory region variant
rs48604184:62,421,204C/Tintron variant
rs5738906874:62,427,056T/C
rs68563284:62,437,318C/Gintron variant
rs7644337934:62,452,981G/Auncertain significance
rs7453519344:62,453,043A/Guncertain significance
rs21728024:62,453,209A/Gintron variant
rs5414827094:62,473,251G/A
rs7669516684:62,542,600C/Tuncertain significance
rs76780464:62,596,693C/A
rs1919153914:62,598,548G/Alikely benign
rs9616316964:62,598,601C/Guncertain significance
rs25486751844:62,598,651A/Guncertain significance
rs3705332784:62,598,666A/Guncertain significance
rs1486165744:62,598,951C/Guncertain significance
rs5539559734:62,599,124G/Tuncertain significance
rs19012234:62,660,731G/Aintron variant
rs25459802754:62,679,598T/Clikely benign
rs65516654:62,739,541G/Aintron variant
rs19472744:62,744,240C/T
rs19472754:62,744,545T/Cintron variant
rs7680313304:62,758,407G/Auncertain significance
rs3737366584:62,758,430C/Tuncertain significance
rs7751383204:62,758,586A/Guncertain significance
rs7789272294:62,758,632G/Auncertain significance
rs7693395944:62,758,673A/Guncertain significance
rs3696952784:62,758,674T/Cuncertain significance
rs7463713614:62,761,541A/Guncertain significance
rs23450394:62,765,030G/Cintron variant
rs68131834:62,769,131G/T
rs1922107274:62,775,333G/Tmissense variant
rs13553684:62,779,822A/T
rs7346444:62,800,728T/Amissense variant
rs7591924394:62,812,663C/Auncertain significance
rs3765557014:62,812,713C/Tuncertain significance
rs7673099344:62,812,757G/Auncertain significance
rs3727850174:62,813,870G/Auncertain significance
rs7543471914:62,813,906G/Auncertain significance
rs3771179854:62,813,929C/Tuncertain significance
rs7773179904:62,813,935A/Guncertain significance
rs12292736944:62,845,398A/Guncertain significance
rs5523482444:62,845,432T/Guncertain significance
rs3700406304:62,845,477G/Auncertain significance
rs286341844:62,873,419C/Tintron variant
rs14715538254:62,894,575A/Guncertain significance
rs13613606224:62,897,296A/Guncertain significance
rs25486112894:62,903,563A/Cuncertain significance
rs12228618864:62,910,180C/Tuncertain significance
rs99980414:62,914,954G/Tintron variant
rs17450989994:62,935,853A/Tuncertain significance
rs7699990334:62,935,952C/Guncertain significance
rs5624760454:62,936,093C/Tuncertain significance
rs24763465654:62,936,096G/Tuncertain significance
rs24763528344:62,936,220A/Cuncertain significance
rs7484483434:62,936,372G/Auncertain significance
rs7714970644:62,936,384G/Auncertain significance
rs7587559044:62,936,450G/Auncertain significance
rs12931408864:62,936,462A/Guncertain significance
rs11633857354:62,936,481G/Auncertain significance
rs24763683634:62,936,489A/Cuncertain significance
rs14295296964:62,936,544G/Tuncertain significance

Gene information from NCBI Gene. Variant classifications from ClinVar.