rs570436

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GWAS Catalog Trait Associations (3)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

alcohol use disorder measurement, alcohol consumption quality

Zhou H et al. “Genome-wide meta-analysis of problematic alcohol use in 435,563 individuals yields insights into biology and relationships with other traits.” Nature Neuroscience 23(7):809-818 (2020)

Allele T

OR 0.02

p 3.0e-23

N 972,915

Meta-analysisLarge GWAS

European

alcohol use disorder measurement, alcohol dependence

Kranzler HR et al. “Genome-wide association study of alcohol consumption and use disorder in 274,424 individuals from multiple populations.” Nature Communications 10(1):1499 (2019)

Allele T

OR 1.06

p 2.0e-10

N 274,391

Large GWAS

multi-ancestry

substance-related disorder

Hatoum AS et al. “Multivariate genome-wide association meta-analysis of over 1 million subjects identifies loci underlying multiple substance use disorders.” Nature. Mental Health 1(3):210-223 (2023)

Allele C

OR —

β 0.015

p 1.0e-9

N 647,703

Meta-analysisLarge GWAS

European

This variant is in our database but has no known associations or PRS memberships yet.

Gene information from NCBI Gene. Variant classifications from ClinVar.

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