rs1800041
This variant is located in the HTR1A gene.
▶ClinVar annotation
▶Research that mentions this SNP (1)
▶A Tryptophan Hydroxylase Gene Marker for Suicidality and AlcoholismReviewDavid A. Nielsen et al.(1998)· Archives of General Psychiatry
This review article systematically examines the genetic and non-genetic contributions of serotonin to suicide risk. Key findings include associations between suicide and polymorphisms in serotonin pathway genes including TPH (A779C, A218C), 5-HTT/SLC6A4 (5-HTTLPR), HTR1A (C-1018G), and HTR2A (T102C, A-1438G, his452tyr), though findings are inconsistent across studies. The review also discusses non-genetic factors such as reduced cerebrospinal fluid 5-HIAA levels and abnormal serotonin receptor densities in postmortem brains of suicide victims.
About HTR1A
This gene encodes a G protein-coupled receptor for 5-hydroxytryptamine (serotonin), and belongs to the 5-hydroxytryptamine receptor subfamily. Serotonin has been implicated in a number of physiologic processes and pathologic conditions. Inactivation of this gene in mice results in behavior consistent with an increased anxiety and stress response. Mutation in the promoter of this gene has been associated with menstrual cycle-dependent periodic fevers. [provided by RefSeq, Jun 2012]
View all HTR1A variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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