rs1801123

This is a synonymous variant in the IRS1 gene — it does not change the protein's amino acid sequence.

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Research that mentions this SNP (1)

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Single‐nucleotide polymorphisms in the p53 pathway genes modify cancer risk in BRCA1 and BRCA2 carriers of Jewish‐Ashkenazi descent
AssociationN=704Ronit I. Yarden et al.(2010)· Molecular Carcinogenesis

This case-cohort study of 704 postmenopausal women examined 33 SNPs in IGF-I, insulin resistance, and related signaling pathway genes. Six SNPs in INS, IGF-I, and IGFBP3 genes and 11 SNPs in IRS1 and AKT1/2 genes were associated with colorectal cancer risk, with associations differing by obesity status, physical activity, and exogenous estrogen use. Approximately 30-50% of the SNP-cancer association was mediated or influenced by IGF-I/IR traits, suggesting gene-lifestyle interactions affect postmenopausal CRC risk.

Traits studied:Colorectal cancerFasting glucoseFasting insulinHOMA-IRIGFBP3 levelsInsulin resistanceInsulin-like growth factor-I levels
PubMedDOIMetascience Observatory

About IRS1

This gene encodes a protein which is phosphorylated by insulin receptor tyrosine kinase. Mutations in this gene are associated with type II diabetes and susceptibility to insulin resistance. [provided by RefSeq, Nov 2009]

View all IRS1 variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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