rs181430930
This variant is located in the MICA gene.
▶ClinVar annotation
not provided; Colon adenocarcinoma; Sarcoma; Gastric cancer; Lymphoma; Ovarian serous cystadenocarcinoma; Uterine corpus endometrial carcinoma; Clear cell carcinoma of kidney; Uterine carcinosarcoma; Lung cancer; Familial cancer of breast; Malignant tumor of urinary bladder; Chronic lymphocytic leukemia/small lymphocytic lymphoma; Malignant lymphoma, large B-cell, diffuse; Thyroid cancer, nonmedullary, 1; Adrenocortical carcinoma, hereditary
View on ClinVar →About MICA
This gene encodes the highly polymorphic major histocompatability complex class I chain-related protein A. The protein product is expressed on the cell surface, although unlike canonical class I molecules it does not seem to associate with beta-2-microglobulin. It is a ligand for the NKG2-D type II integral membrane protein receptor. The protein functions as a stress-induced antigen that is broadly recognized by intestinal epithelial gamma delta T cells. Variations in this gene have been associated with susceptibility to psoriasis 1 and psoriatic arthritis, and the shedding of MICA-related antibodies and ligands is involved in the progression from monoclonal gammopathy of undetermined significance to multiple myeloma. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jan 2014]
View all MICA variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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