rs181857010

This variant is located in the POLD3 gene.

▶

ClinVar annotation

no_classifications_from_unflagged_records

2 submitters1 publication

Immunodeficiency 122; Acute myeloid leukemia; Nonpapillary renal cell carcinoma; Ovarian serous cystadenocarcinoma

About POLD3

This gene encodes the 66-kDa subunit of DNA polymerase delta. DNA polymerase delta possesses both polymerase and 3' to 5' exonuclease activity and plays a critical role in DNA replication and repair. The encoded protein plays a role in regulating the activity of DNA polymerase delta through interactions with other subunits and the processivity cofactor proliferating cell nuclear antigen (PCNA). Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Mar 2012]

View all POLD3 variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

Community Wiki

No community notes yet for this variant. Sign in to start one.

Comments

Loading comments…