rs182651559

This is a intron variant variant in the SLC7A11 gene.

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GWAS Catalog Trait Associations (1)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

sleep duration trait

Li X et al. “Automated feature extraction from population wearable device data identified novel loci associated with sleep and circadian rhythms.” Plos Genetics 16(10):e1009089 (2020)

Allele T

OR 4.99

p 1.0e-8

N 90,515

Large GWAS

About SLC7A11

This gene encodes a member of a heteromeric, sodium-independent, anionic amino acid transport system that is highly specific for cysteine and glutamate. In this system, designated Xc(-), the anionic form of cysteine is transported in exchange for glutamate. This protein has been identified as the predominant mediator of Kaposi sarcoma-associated herpesvirus fusion and entry permissiveness into cells. Also, increased expression of this gene in primary gliomas (compared to normal brain tissue) was associated with increased glutamate secretion via the XCT channels, resulting in neuronal cell death. [provided by RefSeq, Sep 2011]

View all SLC7A11 variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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