rs182766845

This variant is located in the ATRIP gene.

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ClinVar annotation

Benign★☆☆☆

2 submitters1 publication

not provided; Sarcoma; Ovarian serous cystadenocarcinoma; Acute myeloid leukemia; Malignant tumor of esophagus; Chronic lymphocytic leukemia/small lymphocytic lymphoma; Ovarian cancer; Familial pancreatic carcinoma; Familial cancer of breast

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About ATRIP

This gene encodes an essential component of the DNA damage checkpoint. The encoded protein binds to single-stranded DNA coated with replication protein A. The protein also interacts with the ataxia telangiectasia and Rad3 related protein kinase, resulting in its accumulation at intranuclear foci induced by DNA damage. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2012]

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Gene information from NCBI Gene. Variant classifications from ClinVar.

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