rs1828591

This is a intergenic variant variant in the LOC105377462 gene.

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GWAS Catalog Trait Associations (3)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

FEV/FVC ratio, response to bronchodilator

Lutz SM et al. “A genome-wide association study identifies risk loci for spirometric measures among smokers of European and African ancestry.” Bmc Genetics 16:138 (2015)

Allele A

OR —

β 0.012

p 3.0e-12

N 13,532

Large GWAS

multi-ancestry

cryptic phenotype measurement

Blair DR et al. “Common genetic variation associated with Mendelian disease severity revealed through cryptic phenotype analysis.” Nature Communications 13(1):3675 (2022)

Allele G

OR 0.01

p 2.0e-9

N 294,133

Large GWAS

European

forced expiratory volume, response to bronchodilator

Lutz SM et al. “A genome-wide association study identifies risk loci for spirometric measures among smokers of European and African ancestry.” Bmc Genetics 16:138 (2015)

Allele A

OR —

β 0.051

p 4.0e-9

N 13,532

Large GWAS

multi-ancestry

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ClinVar annotation

Association

1 submitter

Chronic obstructive pulmonary disease; Chronic obstructive pulmonary disease, biomass related

View on ClinVar →

This variant is in our database but has no known associations or PRS memberships yet.

Gene information from NCBI Gene. Variant classifications from ClinVar.

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