rs183373024

This is a upstream gene variant variant in the PRNCR1 gene.

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GWAS Catalog Trait Associations (2)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

prostate carcinoma

Wang A et al. “Characterizing prostate cancer risk through multi-ancestry genome-wide discovery of 187 novel risk variants.” Nature Genetics 55(12):2065-2074 (2023)
Allele G
OR 3.18
p —
N 944,762
Large GWAS
multi-ancestry
Conti DV et al. “Trans-ancestry genome-wide association meta-analysis of prostate cancer identifies new susceptibility loci and informs genetic risk prediction.” Nature Genetics 53(1):65-75 (2021)
Allele G
OR 2.27
p 1.0e-80
N 234,253
Meta-analysisLarge GWAS
multi-ancestry
Schumacher FR et al. “Association analyses of more than 140,000 men identify 63 new prostate cancer susceptibility loci.” Nature Genetics 50(7):928-936 (2018)
Allele G
OR 2.91
p 4.0e-160
N 140,254
Large GWAS
European

family history

Jiang L et al. “A generalized linear mixed model association tool for biobank-scale data.” Nature Genetics 53(11):1616-1621 (2021)
Allele G
OR 0.22
p 5.0e-9
N 401,881
Large GWAS
European
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ClinVar annotation

Association
1 submitter1 publication

Familial prostate cancer

View on ClinVar →
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Research that mentions this SNP (1)

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Genome-wide association of familial prostate cancer cases identifies evidence for a rare segregating haplotype at 8q24.21
AssociationN=3,893Teerlink CC et al.(2016)· Human Genetics

This genome-wide association study of 2511 familial prostate cancer cases and 1382 controls identified significant associations in six regions previously linked to prostate cancer risk. Most notably, rs138042437 at 8q24.21 achieved an exceptionally large effect size (OR=13.3, p=1.7e-8) and demonstrated strong co-segregation with disease in 116 affected relatives (p=8.5e-11). The study identified a rare segregating haplotype at 8q24.21 containing three SNPs (rs183373024, rs188140481, rs138042437) that characterized a prostate cancer predisposition locus.

Traits studied:Aggressive prostate cancerFamilial prostate cancerProstate cancer
PubMedDOIMetascience Observatory

This variant is in our database but has no known associations or PRS memberships yet.

Gene information from NCBI Gene. Variant classifications from ClinVar.

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