rs1834306

This is a upstream gene variant variant in the MIR100HG gene.

▶

GWAS Catalog Trait Associations (2)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

smoking initiation

Saunders GRB et al. “Genetic diversity fuels gene discovery for tobacco and alcohol use.” Nature 612(7941):720-724 (2022)

Allele G

OR 0.01

p 4.0e-17

N 2,669,029

Large GWAS

European

smoking status measurement

Liu M et al. “Association studies of up to 1.2 million individuals yield new insights into the genetic etiology of tobacco and alcohol use.” Nature Genetics 51(2):237-244 (2019)

Allele G

OR 0.01

p 2.0e-8

N 1,232,091

Large GWAS

European

▶

Research that mentions this SNP (2)

▶

Genetic variation in MicroRNA genes and risk of oral premalignant lesions

AssociationN=272Clague J. et al.(2010)· Molecular Carcinogenesis

A case-control study of 136 oral premalignant lesion (OPL) patients and 136 matched controls examined 31 SNPs in microRNA biogenesis pathway genes. The variant allele of rs7372209 in mir26a-1 increased OPL risk (OR 2.09, 95% CI 1.23-3.56), as did rs3742330 in DICER (OR 2.09, 95% CI 1.03-4.24), while rs197412 in GEMIN3 reduced risk (OR 0.58, 95% CI 0.33-0.99). A combined analysis of five SNPs with borderline significant associations showed a dramatic cumulative effect on OPL risk (P for trend <0.0001), with the high-risk group having 21-fold increased odds.

Traits studied:Oral premalignant lesions

PubMed DOI Metascience Observatory

▶

Prognostic impact of microRNA-related gene polymorphisms on survival of patients with colorectal cancer

AssociationN=426Hyun-Chul Lee et al.(2010)· Journal of Cancer Research and Clinical Oncology

This study evaluated 40 SNPs in microRNA-related genes for associations with colorectal cancer prognosis in 426 Korean patients. In univariate analysis, mir492 C>G (rs2289030) was significantly associated with progression-free survival (PFS 70.8% for C/C vs 62.6% for C/G vs 60.3% for G/G, P=0.0426), but no associations remained significant in multivariate analysis. The authors concluded that none of the 40 miRNA-related gene polymorphisms tested were independent prognostic markers for surgically resected colorectal cancer.

Traits studied:Colorectal cancer prognosisOverall survivalProgression-free survival

PubMed DOI Metascience Observatory

About MIR100HG

This gene produces long non-coding RNAs that act as regulators of cell proliferation. Alternative promoter usage and splicing results in multiple transcript variants. Some transcript variants may promote growth, while others may act to negatively regulate cell division. [provided by RefSeq, May 2016]