rs1837253

This is a upstream gene variant variant.

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GWAS Catalog Trait Associations (21)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

asthma

Zhou W et al. “Global Biobank Meta-analysis Initiative: Powering genetic discovery across human disease.” Cell Genomics 2(10):100192 (2022)

Allele C

OR 0.10

p 4.0e-104

N 1,800,785

Meta-analysisLarge GWAS

multi-ancestry

Olafsdottir TA et al. “Eighty-eight variants highlight the role of T cell regulation and airway remodeling in asthma pathogenesis.” Nature Communications 11(1):393 (2020)

Allele C

OR 1.11

p 1.0e-44

N 771,388

Large GWAS

European

Valette K et al. “Prioritization of candidate causal genes for asthma in susceptibility loci derived from UK Biobank.” Communications Biology 4(1):700 (2021)

Allele C

OR 0.11

p 1.0e-47

N 408,422

Major Consortium StudyLarge GWAS

European

Verma A et al. “Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.” Science (new York, N.y.) 385(6706):eadj1182 (2024)

Allele C

OR 0.11

p 4.0e-24

N 404,034

Major Consortium StudyLarge GWAS

multi-ancestry

Loya H et al. “A scalable variational inference approach for increased mixed-model association power.” Nature Genetics 57(2):461-468 (2025)

Allele C

OR 0.11

p 1.0e-54

N 394,626

Large GWAS

European

Zhu Z et al. “Shared genetics of asthma and mental health disorders: a large-scale genome-wide cross-trait analysis.” The European Respiratory Journal 54(6) (2019)

Allele C

OR 1.11

p 1.0e-51

N 394,283

Large GWAS

multi-ancestry

Ferreira MAR et al. “Genetic Architectures of Childhood- and Adult-Onset Asthma Are Partly Distinct.” American Journal of Human Genetics 104(4):665-684 (2019)

Allele C

OR 1.11

p 1.0e-41

N 341,215

Large GWAS

European

Jia G et al. “Discerning asthma endotypes through comorbidity mapping.” Nature Communications 13(1):6712 (2022)

Allele C

OR 0.88

p 9.0e-11

N 305,098

Large GWAS

multi-ancestry

Han Y et al. “Genome-wide analysis highlights contribution of immune system pathways to the genetic architecture of asthma.” Nature Communications 11(1):1776 (2020)

Allele C

OR 1.11

p 3.0e-57

N 303,859

Large GWAS

European

Johansson Å et al. “Genome-wide association analysis of 350 000 Caucasians from the UK Biobank identifies novel loci for asthma, hay fever and eczema.” Human Molecular Genetics 28(23):4022-4041 (2019)

Allele C

OR —

p 4.0e-44

N 281,699

Major Consortium StudyLarge GWAS

European

Ishigaki K et al. “Large-scale genome-wide association study in a Japanese population identifies novel susceptibility loci across different diseases.” Nature Genetics 52(7):669-679 (2020)

Allele C

OR 1.14

p 4.0e-14

N 209,808

Large GWAS

East Asian

Sakaue S et al. “A cross-population atlas of genetic associations for 220 human phenotypes.” Nature Genetics 53(10):1415-1424 (2021)

Allele C

OR 0.12

p 1.0e-17

N 175,948

Large GWAS

East Asian

Shrine N et al. “Moderate-to-severe asthma in individuals of European ancestry: a genome-wide association study.” The Lancet. Respiratory Medicine 7(1):20-34 (2019)

Allele C

OR 1.19

p 2.0e-22

N 30,810

Large GWAS

European

Hirota T et al. “Genome-wide association study identifies three new susceptibility loci for adult asthma in the Japanese population.” Nature Genetics 43(9):893-6 (2011)

Allele C

OR 1.17

p 1.0e-16

N 4,836

Large GWAS

East Asian

Nasal Cavity Polyp

Sakaue S et al. “A cross-population atlas of genetic associations for 220 human phenotypes.” Nature Genetics 53(10):1415-1424 (2021)

Allele C

OR 0.28

p 2.0e-32

N 602,065

Large GWAS

multi-ancestry

Kristjansson RP et al. “A loss-of-function variant in ALOX15 protects against nasal polyps and chronic rhinosinusitis.” Nature Genetics 51(2):267-276 (2019)

Allele C

OR 1.35

p 4.0e-29

N 719,047

Large GWAS

European

Loya H et al. “A scalable variational inference approach for increased mixed-model association power.” Nature Genetics 57(2):461-468 (2025)

Allele C

OR 0.28

p 2.0e-13

N 394,626

Large GWAS

European

allergic disease

Ferreira MA et al. “Shared genetic origin of asthma, hay fever and eczema elucidates allergic disease biology.” Nature Genetics 49(12):1752-1757 (2017)

Allele C

OR 1.07

p 2.0e-31

N 360,838

Large GWAS

European

Inhalant adrenergic use measurement

Sakaue S et al. “A cross-population atlas of genetic associations for 220 human phenotypes.” Nature Genetics 53(10):1415-1424 (2021)

Allele C

OR 0.10

p 1.0e-27

N 355,171

Large GWAS

multi-ancestry

Wu Y et al. “Genome-wide association study of medication-use and associated disease in the UK Biobank.” Nature Communications 10(1):1891 (2019)

Allele C

OR 0.10

p 4.0e-23

N 176,445

Major Consortium StudyLarge GWAS

European

childhood onset asthma

Pividori M et al. “Shared and distinct genetic risk factors for childhood-onset and adult-onset asthma: genome-wide and transcriptome-wide studies.” The Lancet. Respiratory Medicine 7(6):509-522 (2019)

Allele C

OR 1.21

p 2.0e-27

N 327,670

Large GWAS

European

eosinophil count

Astle WJ et al. “The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease.” Cell 167(5):1415-1429.e19 (2016)

Allele C

OR 0.04

p 2.0e-22

N 172,275

Large GWAS

European

Vuckovic D et al. “The Polygenic and Monogenic Basis of Blood Traits and Diseases.” Cell 182(5):1214-1231.e11 (2020)

Allele C

OR 0.02

p 1.0e-14

N 408,112

Large GWAS

European

eosinophil percentage of leukocytes

Astle WJ et al. “The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease.” Cell 167(5):1415-1429.e19 (2016)

Allele C

OR 0.04

p 4.0e-21

N 172,378

Large GWAS

European

Vuckovic D et al. “The Polygenic and Monogenic Basis of Blood Traits and Diseases.” Cell 182(5):1214-1231.e11 (2020)

Allele C

OR 0.02

p 8.0e-16

N 408,112

Large GWAS

European

Eczematoid dermatitis, allergic rhinitis

Allele C

OR 1.06

p 3.0e-19

N 323,807

Major Consortium StudyLarge GWAS

European

asthma, chronic obstructive pulmonary disease

John C et al. “Genetic Associations and Architecture of Asthma-COPD Overlap.” Chest 161(5):1155-1166 (2022)

Allele C

OR 1.16

p 2.0e-18

N 48,428

Large GWAS

multi-ancestry

eosinophil percentage of granulocytes

Astle WJ et al. “The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease.” Cell 167(5):1415-1429.e19 (2016)

Allele C

OR 0.04

p 2.0e-18

N 170,536

Large GWAS

European

This variant is in our database but has no known associations or PRS memberships yet.

rs1837253

GWAS Catalog Trait Associations (21)

asthma

Nasal Cavity Polyp

allergic disease

Inhalant adrenergic use measurement

childhood onset asthma

eosinophil count

eosinophil percentage of leukocytes

Eczematoid dermatitis, allergic rhinitis

asthma, chronic obstructive pulmonary disease

eosinophil percentage of granulocytes

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