rs184587444
This is a intron variant variant in the SPRR2B gene.
▶GWAS Catalog Trait Associations (3)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
GWAS Catalog Trait Associations (3)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
allergic disease, age at onset
Ferreira MAR et al. “Age-of-onset information helps identify 76 genetic variants associated with allergic disease.” Plos Genetics 16(6):e1008725 (2020)
Allele T
OR 0.19
p 4.0e-28
N 117,130
Large GWAS
European
allergic disease
Ferreira MAR et al. “Age-of-onset information helps identify 76 genetic variants associated with allergic disease.” Plos Genetics 16(6):e1008725 (2020)
Allele T
OR 0.13
p 4.0e-12
N 477,968
Large GWAS
European
atopic eczema
Chen Y et al. “Genome-Wide Integration of Genetic and Genomic Studies of Atopic Dermatitis: Insights into Genetic Architecture and Pathogenesis.” The Journal of Investigative Dermatology 142(11):2958-2967.e8 (2022)
Allele T
OR 0.29
p 2.0e-9
N 837,496
Large GWAS
multi-ancestry
About SPRR2B
Predicted to be involved in keratinocyte differentiation. Predicted to act upstream of or within response to estradiol. Predicted to be located in cornified envelope and cytosol. [provided by Alliance of Genome Resources, Jul 2025]
View all SPRR2B variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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