rs185780451

This is a regulatory region variant variant in the NIT1 gene.

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GWAS Catalog Trait Associations (1)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

low affinity immunoglobulin gamma Fc region receptor II-b measurement

Loya H et al. “A scalable variational inference approach for increased mixed-model association power.” Nature Genetics 57(2):461-468 (2025)

Allele T

OR 0.29

p 1.0e-13

N 47,745

Large GWAS

European

About NIT1

This gene encodes a member of the nitrilase protein family with homology to bacterial and plant nitrilases, enzymes that cleave nitriles and organic amides to the corresponding carboxylic acids plus ammonia. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2010]

View all NIT1 variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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