rs187084

This case-control study investigated the association between TLR2, TLR3, TLR4, and TLR9 polymorphisms and susceptibility to and prognosis of severe hepatitis among 135 newborn cases and 140 healthy controls of Chinese Han ethnicity. Certain SNPs were associated with disease risk and prognosis, including rs1898830 (TLR2; OR=0.38 for favorable prognosis in AG carriers), rs1879026 (TLR3; OR=0.29 for GT carriers), and rs187084 and rs352139 (TLR9). The haplotype A-C-G-G-C-A-T showed increased susceptibility (OR=4.11), while this haplotype was associated with favorable prognosis when present.

This study investigates the role of TLR9 rs187084 (T-1486C) polymorphism in pulmonary tuberculosis susceptibility. Functional analysis showed that the C allele increases TLR9 transcriptional activity and IP-10 production (a TB biomarker) but decreases protective cytokines IFN-γ and TNF-α. Genotype analysis of three Central Indian tribes revealed the C allele frequency was significantly lower in the TB-resistant Baiga tribe (18%) compared to Gond and Korku tribes (41-42%), supporting rs187084 as a potential TB susceptibility variant.

Case-control study examining the TLR9 C→T (rs352140) polymorphism in 254 Polish SLE patients and 521 controls. While the polymorphism was not associated with overall SLE risk (OR=1.414, p=0.0598), the T/T and T/C genotypes showed significant associations with renal disease (OR=2.949, p=0.001), immunologic disorders (OR=2.938, p=0.0012), and anti-dsDNA antibodies (OR=3.682, p=0.001) in SLE patients.

A systematic literature review examining the association between toll-like receptor (TLR) single nucleotide polymorphisms and susceptibility to hepatitis B virus (HBV) and hepatitis C virus (HCV) infection, including disease progression to liver cirrhosis and hepatocellular carcinoma. The review identifies polymorphisms in TLR2, TLR3, TLR4, TLR5, TLR7, TLR8, and TLR9 genes that affect viral susceptibility and disease outcomes, with mechanisms involving altered gene expression and immune signaling.

Case-control study of 167 Chinese SLE patients and 211 controls in Taiwan examining TLR9 gene polymorphisms. The TLR9 -1486 T/C (rs187084) polymorphism was significantly associated with SLE susceptibility (P < 0.001, OR = 2.23 for T allele), whereas rs2066807 showed no significant association. No associations were found between either TLR9 polymorphism and clinical severity or manifestations.

This case-control association study of 557 Han Chinese trauma patients identified TLR9 gene polymorphisms rs187084 and rs352162 as significantly associated with increased sepsis morbidity (OR 1.36 and 1.40 respectively) and multiple organ dysfunction after major blunt trauma. Both SNPs were associated with elevated TNFα production by peripheral blood leucocytes in response to bacterial DNA stimulation, suggesting functional significance in TLR9-mediated immune activation.

This case-control study of 100 Turkish rheumatoid arthritis (RA) patients and 100 healthy controls investigated associations between toll-like receptor (TLR) gene polymorphisms and RA risk. The TLR9 rs187084 (-1237 T/C) TT genotype was significantly associated with increased RA risk (p = 0.013, χ² = 8.698), and TT allele frequency was higher in patients versus controls (p = 0.003). No significant associations were found for TLR3 rs3775290 or TLR10 rs4129009 polymorphisms with RA or autoantibody production.