rs1874886

This is a upstream gene variant variant in the IL12A-AS1 gene.

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GWAS Catalog Trait Associations (1)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

Behcet's syndrome

Ortiz-Fernández L et al. “Genetic Analysis with the Immunochip Platform in Behçet Disease. Identification of Residues Associated in the HLA Class I Region and New Susceptibility Loci.” Plos One 11(8):e0161305 (2016)

Allele A

OR 1.61

p 2.0e-8

N 1,795

Large GWAS

European

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Research that mentions this SNP (1)

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Identification of a susceptibility locus in STAT4 for Behçet's disease in Han Chinese in a genome‐wide association study

AssociationN=4,539Shengping Hou et al.(2012)· Arthritis & Rheumatism

This Immunochip-based genetic analysis of Behçet's disease in a Spanish population (278 cases, 1,517 controls; 130 cases, 605 controls in replication) identified HLA-B*51 as the primary susceptibility marker (P=6.82E-32, OR=3.82), with independent signals from HLA-B*57 and HLA-A*03. Outside the HLA region, the study confirmed IL23R (rs10889664: P=3.81E-12, OR=2.00), IL12A (rs1874886: P=1.62E-08, OR=1.61), and identified a novel association in the JRKL/CNTN5 region (rs2848479: P=3.29E-10, OR=1.66).

Traits studied:Behçet's disease

PubMed DOI Metascience Observatory

This variant is in our database but has no known associations or PRS memberships yet.

rs1874886

GWAS Catalog Trait Associations (1)

Behcet's syndrome

Research that mentions this SNP (1)

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