rs1879585

This is a intron variant variant in the PLEKHM1 gene.

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GWAS Catalog Trait Associations (1)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

brain age measurement

Zhao X et al. “Regulatory Genomic Circuitry of Brain Age by Integrative Functional Genomic Analyses.” Genomics, Proteomics & Bioinformatics 23(5) (2025)

Allele G

OR 0.24

p 6.0e-15

N 35,702

Large GWAS

European

About PLEKHM1

The protein encoded by this gene is essential for bone resorption, and may play a critical role in vesicular transport in the osteoclast. Mutations in this gene are associated with autosomal recessive osteopetrosis type 6 (OPTB6). Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2009]

View all PLEKHM1 variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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