rs1889473

This variant is located in the LRP11 gene.

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GWAS Catalog Trait Associations (2)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

cerebrospinal fluid composition attribute, 5-methylthioadenosine (MTA) measurement

Wang C et al. “Genetic architecture of cerebrospinal fluid and brain metabolite levels and the genetic colocalization of metabolites with human traits.” Nature Genetics 56(12):2685-2695 (2024)

Allele C

OR 0.02

p 4.0e-16

N 2,602

Large GWAS

European

level of inosine triphosphate pyrophosphatase in blood serum

Kuliesius J et al. “Efficient candidate drug target discovery through proteogenomics in a Scottish cohort.” Communications Biology 8(1):1300 (2025)

Allele G

OR 0.76

p 2.0e-15

N 199

Small GWAS

European

About LRP11

Enables phosphoprotein binding activity. Predicted to be involved in several processes, including response to cold; response to heat; and response to water deprivation. Predicted to be located in plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

View all LRP11 variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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