rs189411872

This is a intron variant variant in the ADAM23 gene.

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GWAS Catalog Trait Associations (2)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

disorder of pharynx

Saarentaus EC et al. “Inflammatory and infectious upper respiratory diseases associate with 41 genomic loci and type 2 inflammation.” Nature Communications 14(1):83 (2023)
Allele G
OR 1.40
p 3.0e-15
N 232,365
Large GWAS
European

upper respiratory tract disorder

Saarentaus EC et al. “Inflammatory and infectious upper respiratory diseases associate with 41 genomic loci and type 2 inflammation.” Nature Communications 14(1):83 (2023)
Allele G
OR 1.20
p 2.0e-8
N 260,405
Large GWAS
European

About ADAM23

This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. It is reported that inactivation of this gene is associated with tumorigenesis in human cancers. [provided by RefSeq, May 2013]

View all ADAM23 variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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