rs1902023

This is a missense variant in the UGT2B15 gene.

Key Literature Trait Associations

Benzodiazepine Metabolism

UGT2B15 D85Y (rs1902023) is a common missense variant in UDP-glucuronosyltransferase 2B15. The Tyr85 variant (A allele, *2 allele) reduces enzymatic glucuronidation activity, leading to significantly slower clearance of lorazepam (42% reduction) and oxazepam (52% reduction) in homozygous carriers. This may necessitate benzodiazepine dose adjustments to avoid prolonged sedation.

Court MH et al. “UGT2B15 D85Y genotype and gender are major determinants of oxazepam glucuronidation by human liver” The Journal of Pharmacology and Experimental Therapeutics (2004)

Allele A

OR —

p —

Candidate gene study

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GWAS Catalog Trait Associations (10)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

X-17340 measurement

Surendran P et al. “Rare and common genetic determinants of metabolic individuality and their effects on human health.” Nature Medicine 28(11):2321-2332 (2022)

Allele A

OR 0.25

p 3.0e-125

N 14,296

Large GWAS

European

vanillylmandelate (VMA) measurement

Feofanova EV et al. “Whole-Genome Sequencing Analysis of Human Metabolome in Multi-Ethnic Populations.” Nature Communications 14(1):3111 (2023)

Allele C

OR 0.21

p 1.0e-42

N 7,906

Large GWAS

multi-ancestry

serum gamma-glutamyl transferase measurement

Sakaue S et al. “A cross-population atlas of genetic associations for 220 human phenotypes.” Nature Genetics 53(10):1415-1424 (2021)

Allele C

OR 0.02

p 2.0e-35

N 477,575

Large GWAS

multi-ancestry

X-24418 measurement

Chen Y et al. “Genomic atlas of the plasma metabolome prioritizes metabolites implicated in human diseases.” Nature Genetics 55(1):44-53 (2023)

Allele C

OR 0.20

p 4.0e-31

N 5,952

Large GWAS

European

Schlosser P et al. “Genetic studies of paired metabolomes reveal enzymatic and transport processes at the interface of plasma and urine.” Nature Genetics 55(6):995-1008 (2023)

Allele C

OR 0.15

p 3.0e-15

N 4,849

Large GWAS

European

5alpha-androstan-3alpha,17beta-diol 17-glucuronide measurement

Feofanova EV et al. “Whole-Genome Sequencing Analysis of Human Metabolome in Multi-Ethnic Populations.” Nature Communications 14(1):3111 (2023)

Allele C

OR 0.27

p 8.0e-25

N 3,061

Large GWAS

multi-ancestry

sex hormone-binding globulin measurement

Harrison S et al. “Testosterone and socioeconomic position: Mendelian randomization in 306,248 men and women in UK Biobank.” Science Advances 7(31) (2021)

Allele C

OR 0.77

p 5.0e-23

N 148,248

Major Consortium StudyLarge GWAS

European

level of serpin A11 in blood

Loya H et al. “A scalable variational inference approach for increased mixed-model association power.” Nature Genetics 57(2):461-468 (2025)

Allele C

OR 0.03

p 4.0e-13

N 47,745

Large GWAS

European

X-21286 measurement

Surendran P et al. “Rare and common genetic determinants of metabolic individuality and their effects on human health.” Nature Medicine 28(11):2321-2332 (2022)

Allele A

OR 0.07

p 6.0e-12

N 14,296

Large GWAS

European

testosterone measurement

Pagadala MS et al. “Discovery of novel ancestry specific genes for androgens and hypogonadism in Million Veteran Program Men.” Nature Communications 16(1):4104 (2025)

Allele C

OR 0.03

p 3.0e-10

N 95,184

Major Consortium StudyLarge GWAS

European

metabolite measurement

Chen Y et al. “Genomic atlas of the plasma metabolome prioritizes metabolites implicated in human diseases.” Nature Genetics 55(1):44-53 (2023)

Allele C

OR 0.13

p 2.0e-12

N 5,856

Large GWAS

European

Schlosser P et al. “Genetic studies of paired metabolomes reveal enzymatic and transport processes at the interface of plasma and urine.” Nature Genetics 55(6):995-1008 (2023)

Allele C

OR 0.24

p 5.0e-23

N 4,774

Large GWAS

European

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Research that mentions this SNP (2)

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UGT2B17 gene deletion associated with an increase in bone mineral density similar to the effect of hormone replacement in postmenopausal women

AssociationN=2,379Giroux S. et al.(2012)· Osteoporosis International

UGT2B17 gene deletion was associated with significantly higher bone mineral density (BMD) at the femoral neck and lumbar spine in postmenopausal women who never used hormone replacement therapy (HRT), with effect sizes of 0.25-0.32 standard deviations. This association was not observed in premenopausal women or in postmenopausal women who used HRT. The study replicated previous findings in a large sample of 2,379 women and showed that UGT2B17 null carriers did not benefit from HRT for bone density.

Traits studied:Bone mineral densityOsteoporosis

PubMed DOI Metascience Observatory

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Allelic imbalance (AI) identifies novel tissue-specificcis-regulatory variation for humanUGT2B15

FunctionalN=112Chang Sun et al.(2010)· Human Mutation

This functional study identifies cis-regulatory variants controlling UGT2B15 expression through allelic imbalance analysis. The coding variant rs1902023 (D85Y) shows allele-specific expression in liver but not breast tissue. Reporter assays confirm that two promoter SNPs (rs34010522 and rs35513228) regulate expression with ~20% activity difference in liver (P<0.001), and ChIP assays show rs34010522 lies within an Nrf2 transcription factor binding site.

rs1902023

Key Literature Trait Associations

Benzodiazepine Metabolism

GWAS Catalog Trait Associations (10)

X-17340 measurement

vanillylmandelate (VMA) measurement

serum gamma-glutamyl transferase measurement

X-24418 measurement

5alpha-androstan-3alpha,17beta-diol 17-glucuronide measurement

sex hormone-binding globulin measurement

level of serpin A11 in blood

X-21286 measurement

testosterone measurement

metabolite measurement

Research that mentions this SNP (2)

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