rs1919128

This is a protein-altering variant in the C2orf16 gene.

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GWAS Catalog Trait Associations (4)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

glomerular filtration rate

Lee DJ et al. “Genome-wide association study and fine-mapping on Korean biobank to discover renal trait-associated variants.” Kidney Research and Clinical Practice 43(3):299-312 (2024)

Allele A

OR 0.51

p 2.0e-14

N 58,406

Large GWAS

East Asian

triglyceride measurement, metabolic syndrome

Kraja AT et al. “A bivariate genome-wide approach to metabolic syndrome: STAMPEED consortium.” Diabetes 60(4):1329-39 (2011)

Allele A

OR 0.18

p 2.0e-9

N 22,161

Major Consortium StudyLarge GWAS

European

blood glucose amount

Mahajan A et al. “Identification and functional characterization of G6PC2 coding variants influencing glycemic traits define an effector transcript at the G6PC2-ABCB11 locus.” Plos Genetics 11(1):e1004876 (2015)

Allele G

OR 0.02

p 4.0e-9

N 33,231

Large GWAS

European

blood insulin amount

Mahajan A et al. “Identification and functional characterization of G6PC2 coding variants influencing glycemic traits define an effector transcript at the G6PC2-ABCB11 locus.” Plos Genetics 11(1):e1004876 (2015)

Allele G

OR 0.02

p 2.0e-8

N 30,825

Large GWAS

European

This variant is in our database but has no known associations or PRS memberships yet.

Gene information from NCBI Gene. Variant classifications from ClinVar.

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