rs1948948

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GWAS Catalog Trait Associations (4)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

white matter hyperintensity measurement

Zhukovsky P et al. “Genetic influences on brain and cognitive health and their interactions with cardiovascular conditions and depression.” Nature Communications 15(1):5207 (2024)
Allele C
OR 6.66
p 3.0e-11
N 30,708
Large GWAS
European
Sargurupremraj M et al. “Cerebral small vessel disease genomics and its implications across the lifespan.” Nature Communications 11(1):6285 (2020)
Allele C
OR 0.04
p 2.0e-10
N 46,055
Large GWAS
European
Smith SM et al. “An expanded set of genome-wide association studies of brain imaging phenotypes in UK Biobank.” Nature Neuroscience 24(5):737-745 (2021)
Allele C
OR 0.06
p 1.0e-9
N 21,381
Major Consortium StudyLarge GWAS
European

cerebral small vessel disease

Mishra A et al. “Gene-mapping study of extremes of cerebral small vessel disease reveals TRIM47 as a strong candidate.” Brain : a Journal of Neurology 145(6):1992-2007 (2022)
Allele C
OR 1.17
p 1.0e-8
N 19,721
Large GWAS
European

hypertension, white matter hyperintensity measurement

Sargurupremraj M et al. “Cerebral small vessel disease genomics and its implications across the lifespan.” Nature Communications 11(1):6285 (2020)
Allele C
OR —
p 7.0e-9
N 48,524
Large GWAS
multi-ancestry

neuroimaging measurement

Smith SM et al. “An expanded set of genome-wide association studies of brain imaging phenotypes in UK Biobank.” Nature Neuroscience 24(5):737-745 (2021)
Allele T
OR 0.07
p 1.0e-11
N 20,859
Major Consortium StudyLarge GWAS
European

This variant is in our database but has no known associations or PRS memberships yet.

Gene information from NCBI Gene. Variant classifications from ClinVar.

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