rs197056

This variant is located in the SSTR5 gene.

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GWAS Catalog Trait Associations (2)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

IGF-1 measurement

Sinnott-Armstrong N et al. “Genetics of 35 blood and urine biomarkers in the UK Biobank.” Nature Genetics 53(2):185-194 (2021)

Allele G

OR 0.03

p 1.0e-39

N 353,824

Major Consortium StudyLarge GWAS

multi-ancestry

health trait

Schoeler T et al. “Combining cross-sectional and longitudinal genomic approaches to identify determinants of cognitive and physical decline.” Nature Communications 16(1):4524 (2025)

Allele A

OR 0.01

p 3.0e-14

N 405,979

Large GWAS

European

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Research that mentions this SNP (1)

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Insulin‐like growth factor pathway genes and blood concentrations, dietary protein and risk of prostate cancer in the NCI Breast and Prostate Cancer Cohort Consortium (BPC3)

AssociationN=10,216Tsilidis KK et al.(2013)· International Journal of Cancer

This nested case-control study (5,253 cases, 4,963 controls) examined 16 SNPs in IGF pathway genes and their associations with prostate cancer risk, testing gene-environment interactions with dietary protein intake. Although the 16 SNPs were significantly associated with circulating IGF-1 or IGFBP-3 levels as expected, none were significantly associated with prostate cancer risk, and the SNP-protein interactions did not substantially differ by protein intake after multiple testing correction.

Traits studied:IGF-1 concentrationsIGFBP-3 concentrationsProstate cancer

PubMed DOI Metascience Observatory

About SSTR5

Somatostatin and its related peptide cortistatin exert multiple biological actions on normal and tumoral tissue targets by interacting with somatostatin receptors (SSTRs). The protein encoded by this gene is one of the SSTRs, which is a multi-pass membrane protein and belongs to the G-protein coupled receptor 1 family. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase, and different regions of this receptor molecule are required for the activation of different signaling pathways. A mutation in this gene results in somatostatin analog resistance. Alternatively spliced transcript variants have been identified in this gene.[provided by RefSeq, Feb 2010]