rs1989787

This is a regulatory region variant variant.

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GWAS Catalog Trait Associations (1)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

level of ADAMTS-like protein 2 in blood serum

Loya H et al. “A scalable variational inference approach for increased mixed-model association power.” Nature Genetics 57(2):461-468 (2025)
Allele T
OR 0.04
p 1.0e-12
N 47,745
Large GWAS
European
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Research that mentions this SNP (1)

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Linkage analysis of plasma dopamine β-hydroxylase activity in families of patients with schizophrenia
AssociationN=284Joseph F. Cubells et al.(2011)· Human Genetics

This linkage study examined plasma dopamine beta-hydroxylase (pDBH) activity in 284 individuals from 123 families of schizophrenia patients. Strong linkage was confirmed between DBH gene markers and pDBH activity (maximum multipoint LOD score 6.33), with rs1611115 showing the strongest association (p=1.14×10⁻¹⁸). The three key DBH variants rs1611115, rs1611122, and rs6271 accounted for 40% of genetic variation. A novel linkage signal was identified on chromosome 20p12 (LOD=3.1), while no support was found for previously reported linkage on chromosome 19.

Traits studied:Plasma dopamine beta-hydroxylase activityPsychotic symptomsSchizophrenia
PubMedDOIMetascience Observatory

This variant is in our database but has no known associations or PRS memberships yet.

Gene information from NCBI Gene. Variant classifications from ClinVar.

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